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Author (up) Acuna, M.; Eaton, L.; Ramirez, N.R.; Cifuentes, L.; Llop, E. pdf  doi
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  Title Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians Type Journal Article
  Year 2003 Publication American Journal Of Physical Anthropology Abbreviated Journal Am. J. Phys. Anthropol.  
  Volume 121 Issue 1 Pages 81-85  
  Keywords plasma butyrylcholinesterase; BCHE locus; genetic variants; Mapuche Indians  
  Abstract We estimated the frequencies of serum butyrylcholinesterase (BChE) alleles in three tribes of Mapuche Indians from southern Chile, using enzymatic methods, and we estimated the frequency of allele BCHE*K in one tribe using primer reduced restriction analysis (PCR-PIRA). The three tribes have different degrees of European admixture, which is reflected in the observed frequencies of the atypical allele BCHE*A: 1.11% in Huilliches, 0.89% in Cuncos, and 0% in Pehuenches. This result is evidence in favor of the hypothesis that BCHE*A is absent in native Amerindians. The frequencies of BCHE*F were higher than in most reported studies (3.89%, 5.78%, and 4.41%, respectively). These results are probably due to an overestimation of the frequency of allele BCHE*F, since none of the 20 BCHE UF individuals (by the enzymatic test) individuals analyzed showed either of the two DNA base substitutions associated with this allele. Although enzymatic methods rarely detect the presence of allele BCHE*K, PCR-PIRA found the allele in an appreciable frequency (5.76%), although lower than that found in other ethnic groups. Since observed frequencies of unusual alleles correspond to estimated percentages of European admixture, it is likely that none of these unusual alleles were present in Mapuche Indians before the arrival of Europeans. (C) 2003 Wiley-Liss, Inc.  
  Address Univ Santiago Chile, Fac Med, Programa Genet, ICBM, Santiago 70061 7, Chile, Email: macuna@machi.med.uchile.cl  
  Corporate Author Thesis  
  Publisher Wiley-Liss Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9483 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000182336300010 Approved no  
  Call Number UAI @ eduardo.moreno @ Serial 37  
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