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Author (up) Aiyangar, A.K.; Vivanco, J.; Au, A.G.; Anderson, P.A.; Smith, E.L.; Ploeg, H.L. pdf  doi
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  Title Dependence of Anisotropy of Human Lumbar Vertebral Trabecular Bone on Quantitative Computed Tomography-Based Apparent Density Type Journal Article
  Year 2014 Publication Journal Of Biomechanical Engineering-Transactions Of The Asme Abbreviated Journal J. Biomech. Eng.-Trans. ASME  
  Volume 136 Issue 9 Pages 10 pp  
  Keywords human lumbar vertebrae; trabecular bone; anisotropic ratio; transverse isotropy; elastic modulus-density relationship; strain-density relationship  
  Abstract Most studies investigating human lumbar vertebral trabecular bone (HVTB) mechanical property-density relationships have presented results for the superior-inferior (SI), or “ on-axis” direction. Equivalent, directly measured data from mechanical testing in the transverse (TR) direction are sparse and quantitative computed tomography (QCT) density-dependent variations in the anisotropy ratio of HVTB have not been adequately studied. The current study aimed to investigate the dependence of HVTB mechanical anisotropy ratio on QCT density by quantifying the empirical relationships between QCT-based apparent density of HVTB and its apparent compressive mechanical propertieselastic modulus (E-app), yield strength (sigma(y)), and yield strain (epsilon(y))-in the SI and TR directions for future clinical QCT-based continuum finite element modeling of HVTB. A total of 51 cylindrical cores (33 axial and 18 transverse) were extracted from four L1 human lumbar cadaveric vertebrae. Intact vertebrae were scanned in a clinical resolution computed tomography (CT) scanner prior to specimen extraction to obtain QCT density, rho(CT). Additionally, physically measured apparent density, computed as ash weight over wet, bulk volume, rho(app), showed significant correlation with rho(CT) [rho(CT) = 1.0568 x rho(app), r = 0.86]. Specimens were compression tested at room temperature using the Zetos bone loading and bioreactor system. Apparent elastic modulus (E-app) and yield strength (sigma(y)) were linearly related to the rho(CT) in the axial direction [E-SI = 1493.8 x (rho(CT)), r = 0.77, p < 0.01; sigma(Y,SI) = 6.9 x (rho(CT)) = 0.13, r = 0.76, p < 0.01] while a power-law relation provided the best fit in the transverse direction [E-TR 3349.1 x (rho(CT))(1.94), r = 0.89, p < 0.01; sigma(Y,TR) 18.81 x (rho(CT)) 1.83, r = 0.83, p < 0.01]. No significant correlation was found between epsilon(y) and rho(CT) in either direction. E-app and sigma(y) in the axial direction were larger compared to the transverse direction by a factor of 3.2 and 2.3, respectively, on average. Furthermore, the degree of anisotropy decreased with increasing density. Comparatively, epsilon(y) exhibited only a mild, but statistically significant anisotropy: transverse strains were larger than those in the axial direction by 30%, on average. Ability to map apparent mechanical properties in the transverse direction, in addition to the axial direction, from CT-based densitometric measures allows incorporation of transverse properties in finite element models based on clinical CT data, partially offsetting the inability of continuum models to accurately represent trabecular architectural variations.  
  Address [Aiyangar, Ameet K.] EMPA Swiss Fed Labs Mat Sci & Technol Dubendorf, Lab Mech Syst Engn 304, CH-8600 Dubendorf, Switzerland, Email: ameetaiyangar@gmail.com  
  Corporate Author Thesis  
  Publisher Asme Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0148-0731 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000340617700003 Approved no  
  Call Number UAI @ eduardo.moreno @ Serial 401  
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