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Author Selcho, M.; Millan, C.; Palacios-Munoz, A.; Ruf, F.; Ubillo, L.; Chen, J.T.; Bergmann, G.; Ito, C.; Silva, V.; Wegener, C.; Ewer, J. doi  openurl
  Title Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila Type Journal Article
  Year 2017 Publication Nature Communications Abbreviated Journal Nat. Commun.  
  Volume 8 Issue Pages 13 pp  
  Keywords  
  Abstract Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.  
  Address [Selcho, Mareike; Ruf, Franziska; Chen, Jiangtian; Bergmann, Gregor; Ito, Chihiro; Wegener, Christian] Univ Wurzburg, Theodor Boveri Inst, Neurobiol & Genet, Bioctr, D-97074 Wurzburg, Germany, Email: christian.wegener@biozentrum.uni-wuerzburg.de;  
  Corporate Author Thesis  
  Publisher Nature Publishing Group Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2041-1723 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000402306200001 Approved (up) no  
  Call Number UAI @ eduardo.moreno @ Serial 736  
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