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Author (up) Selcho, M.; Millan, C.; Palacios-Munoz, A.; Ruf, F.; Ubillo, L.; Chen, J.T.; Bergmann, G.; Ito, C.; Silva, V.; Wegener, C.; Ewer, J.
Title Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila Type Journal Article
Year 2017 Publication Nature Communications Abbreviated Journal Nat. Commun.
Volume 8 Issue Pages 13 pp
Abstract Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.
Address [Selcho, Mareike; Ruf, Franziska; Chen, Jiangtian; Bergmann, Gregor; Ito, Chihiro; Wegener, Christian] Univ Wurzburg, Theodor Boveri Inst, Neurobiol & Genet, Bioctr, D-97074 Wurzburg, Germany, Email: christian.wegener@biozentrum.uni-wuerzburg.de;
Corporate Author Thesis
Publisher Nature Publishing Group Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2041-1723 ISBN Medium
Area Expedition Conference
Notes WOS:000402306200001 Approved no
Call Number UAI @ eduardo.moreno @ Serial 736
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