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Carreno, A.; Aros, A.E.; Otero, C.; Polanco, R.; Gacitua, M.; Arratia-Perez, R.; Fuentes, J.A. |
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Title |
Substituted bidentate and ancillary ligands modulate the bioimaging properties of the classical Re(I) tricarbonyl core with yeasts and bacteria (vol 41, pg 2140, 2017) |
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Year |
2017 |
Publication |
New Journal Of Chemistry |
Abbreviated Journal |
New J. Chem. |
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Volume |
41 |
Issue |
7 |
Pages |
2826-2826 |
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Address |
[Carreno, Alexander; Arratia-Perez, Ramiro] Univ Andres Bello, Ctr Appl Nanosci CENAP, Republ 275, Santiago, Chile, Email: acarreno@uc.cl; |
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Royal Soc Chemistry |
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English |
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ISSN |
1144-0546 |
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WOS:000401528400033 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
734 |
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Author |
Carreno, A.; Gacitua, M.; Fuentes, J.A.; Paez-Hernandez, D.; Araneda, C.; Chavez, I.; Soto-Arriaza, M.; Manriquez, J.M.; Polanco, R.; Mora, G.C.; Otero, C.; Swords, W.B.; Arratia-Perez, R. |
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Title |
Theoretical and experimental characterization of a novel pyridine benzimidazole: suitability for fluorescence staining in cells and antimicrobial properties |
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Year |
2016 |
Publication |
New Journal Of Chemistry |
Abbreviated Journal |
New J. Chem. |
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Volume |
40 |
Issue |
3 |
Pages |
2362-2375 |
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Abstract |
Benzimidazoles presenting intramolecular hydrogen bonding interactions have been normally used to better understand the role of H-bonding in biological processes. Here, we present an experimental and theoretical study of a new compound [2,4-di-tert-butyl-6-(3H-imidazo[4,5-c]pyridine-2-yl)phenol]; (B2), a benzimidazole derivate, exhibiting an intramolecular hydrogen bond. B2 was synthesized and characterized by its H-1, HHCOSY, FT-IR and mass spectra (EI-MS 323 M+). The electronic and optical properties of B2 were studied with theoretical calculations using density functional theory (DFT) and time-dependent DFT (TDDFT). B2 showed luminescent emission at room temperature in different solvents, with a large Stokes shift (e.g.; lambda(ex) = 335 nm; lambda(em) = 510 nm in acetonitrile). Also, the quantum yield (phi = 0.21) and theoretical band emission are reported. We found that B2 exhibited a fluorescence emission at around 500 nm in ethanol and in acetonitrile that could be quenched by aqueous solutions of Hg(NO3)(2) in the range of micro molar concentrations. Cyclic voltammetry in acetonitrile showed a strong anodic response due to a quasireversible process, with reduction and oxidation waves at -1.28 and -0.47 V vs. SCE. Regarding the biological properties, we assessed the antimicrobial activity of B2 in Salmonella enterica (bacteria), Cryptococcus spp. (yeast), Candida albicans (yeast), Candida tropicalis (yeast) and Botrytis cinerea (mold). To this end, we determined the minimal inhibitory concentration (MIC) (for bacteria and yeasts), the growth inhibition halos (for yeasts), and the inhibition of mycelial growth (for the mold). We observed that B2 exerted an antifungal effect against Cryptococcus spp. and Botrytis cinerea. In addition, due to its fluorescence properties, B2 has proven to be a suitable marker to observe bacteria (Salmonella enterica and an Escherichia coli derivative), yeasts (Candida albicans), and even human cells (SKOV-3 and HEK-293) by confocal microscopy. |
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Address |
[Carreno, Alexander; Paez-Hernandez, Dayan; Arratia-Perez, Ramiro] Univ Andres Bello, Ctr Appl Nanosci CENAP, Doctorado Fisicoquim Mol, Ave Republ 275, Santiago, Chile, Email: acarreno@uc.cl |
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Royal Soc Chemistry |
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English |
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1144-0546 |
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WOS:000372425600059 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
605 |
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Author |
Carreno, A.; Gacitua, M.; Fuentes, J.A.; Paez-Hernandez, D.; Penaloza, J.P.; Otero, C.; Preite, M.; Molins, E.; Swords, W.B.; Meyer, G.J.; Manriquez, J.M.; Polanco, R.; Chavez, I.; Arratia-Perez, R. |
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Title |
Fluorescence probes for prokaryotic and eukaryotic cells using Re(CO)(3)(+) complexes with an electron withdrawing ancillary ligand |
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Year |
2016 |
Publication |
New Journal Of Chemistry |
Abbreviated Journal |
New J. Chem. |
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Volume |
40 |
Issue |
9 |
Pages |
7687-7700 |
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Abstract |
Research in fluorescence microscopy presents new challenges, especially with respect to the development of new metal-based fluorophores. In this work, new fac-[Re(CO)(3)(bpy)L]PF6 (C3) and fac[ Re(CO)(3)(dmb)L]PF6 (C4) complexes, where L is an ancillary ligand, E-2-((3-amino-pyridin-4-ylimino)-methyl)-4,6-di-tert-butylphenol, both exhibiting an intramolecular hydrogen bond, have been synthesized for use as preliminary probes for fluorescence microscopy. The complexes were characterized using chemical techniques such as UV-vis, H-1-NMR, TOCSY, FT-IR, cyclic voltammetry, mass spectrometry (EI-MS 752.22 M+ for C3 and 780.26 M+ for C4) and DFT calculations including spin-orbit effects. The electron withdrawing nature of the ancillary ligand L in C3 and C4 explains their electrochemical behavior, which shows the oxidation of Re-I at 1.84 V for C3 and at 1.88 V for C4. The UV-vis absorption and emission properties have been studied at room temperature in acetonitrile solution. The complexes show luminescent emission with a large Stokes shift (lambda(ex) = 366 nm, lambda(em) = 610 nm for C3 and lambda(ex) = 361 nm, lambda(em) = 560 nm for C4). The TDDFT calculations suggest that an experimental mixed absorption band at 360 nm could be assigned to MLCT (d(Re) -> pi*(dmb)) and LLCT (pi(L) -> pi*(dmb)) transitions. We have also assessed the cytotoxicity of C3 and C4 in an epithelial cell line (T84). We found that 12.5 μg ml(-1) of C3 or C4 is the minimum concentration needed to kill 80% of the cell population, as determined by neutral red uptake. Finally, the potential of C3 and C4 as biological dyes for use in fluorescent microscopy was assessed in bacteria (Salmonella enterica) and yeasts (Candida albicans and Cryptococcus spp.), and in an ovarian cancer cell line (SKOV-3). We found that in all cases, both C3 and C4 are suitable compounds to be used as fluorescent dyes for biological purposes. In addition, we present evidence suggesting that these rhenium(I) tricarbonyl complexes may be also useful as differential fluorescent dyes in yeasts (Candida albicans and Cryptococcus spp.), without the need for antibodies. |
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[Carreno, A.; Paez-Hernandez, D.; Arratia-Perez, R.] Univ Andres Bello, Ctr Appl Nanosci CENAP, Fisicoquim Mol, Republ 275, Santiago, Chile, Email: acarreno@uc.cl; |
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Royal Soc Chemistry |
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English |
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Series Volume |
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1144-0546 |
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Notes |
WOS:000382820000056 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
656 |
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Author |
Karthikeyan, C.; Sisubalan, N.; Varaprasad, K.; Aepuru, R.; Yallapu, M.M.; Mangalaraja, R.V.; Umaralikhan.; Sadiku, R. |
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Title |
Hybrid nanoparticles from chitosan and nickel for enhanced biocidal activities |
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Year |
2022 |
Publication |
New Journal Of Chemistry |
Abbreviated Journal |
New J. Chem. |
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Volume |
46 |
Issue |
27 |
Pages |
13240-13248 |
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Keywords |
ANTIBACTERIAL; CANCER; RESISTANCE |
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Abstract |
Chitosan (Cs) is highly useful for its 'tunable' function, hence allowing numerous optimizable applications in various fields, including the pharmaceutical industry. This has piqued the medicinal chemist's interest in developing innovative synthetic methodologies to produce a biologically optimistic pharmacophore. In order to design a highly environment-friendly artificial process for the production of Cs/Ni/NiO, hybrid nanoparticles (HNPs) were prepared by an inexpensive chemical synthesis method. The synthesized HNPs were characterized by XRD, DLS, and ATR-FTIR analyses. The morphology and elemental analyses of Cs/Ni/NiO HNPs were investigated using FESEM, TEM, and EDX procedures. Cs/Ni/NiO HNPs bactericidal activity was significant for inhibiting pathogenic bacterial strains, namely, S. aureus and E. coli. Furthermore, Cs/Ni/NiO HNPs exhibited potent cytotoxicity against MCF-7. The findings of the study on the biocompatibility of Cs/Ni/NiO HNPs on the L929 cell lines showed a non-cytotoxic tendency toward normal cells. As a result, the report demonstrated that the chemically engineered Cs/Ni/NiO HNPs have biological properties that are effective against MDR pathogenic bacteria and carcinoma cells. More research is, however, needed to ascertain whether improving the morphology of these Cs/Ni/NiO HNPs will enhance their antibacterial and anticancer properties. |
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1144-0546 |
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Notes |
WOS:000814528600001 |
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Call Number |
UAI @ alexi.delcanto @ |
Serial |
1608 |
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Author |
Suresh, R.; Alvarez, A.; Sandoval, C.; Ramirez, E.; Santander, P.; Mangalaraja, R.V.; Yanez, J. |
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Title |
Fe2O3/NiO nanocomposites: synthesis, characterization and roxarsone sensing by Fourier transform infrared photoacoustic spectroscopy |
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Year |
2023 |
Publication |
New Journal Of Chemistry |
Abbreviated Journal |
New J. Chem. |
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Volume |
47 |
Issue |
27 |
Pages |
12806-12815 |
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Keywords |
ALPHA-FE2O3 NANOPARTICLES; ORGANOARSENIC COMPOUNDS; OXIDE; PERFORMANCE; ADSORPTION |
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Abstract |
The Fe2O3/NiO nanocomposite was prepared through facile mixing of pure Fe2O3 and NiO nanoparticles. Pure metal oxides were synthesized by the glycine aided hydrothermal method. The crystal structure was determined by X-ray diffraction (XRD) analysis. Both scanning electron microscopy (SEM) and transmission electron microscopy (TEM) clearly show that the NiO nanospheres were homogeneously distributed on Fe2O3 nanoplates. Fourier transform infrared (FTIR) spectra reveal that functionalization by glycine induces carboxylic and amino groups on the surface of nanoparticles. The optical properties such as light absorption behavior and band gap of the Fe2O3/NiO nanocomposite were determined by UV-Visible diffuse reflectance spectroscopy (DRS UV-Vis). The roxarsone (ROX) sensing behavior of the Fe2O3/NiO nanocomposite was evaluated by using Fourier transform infrared (FTIR) – photoacoustic spectroscopy (PAS) that allowed quantitative sensing of the ROX@Fe2O3/NiO complex. The photoacoustic signals of ROX were clearly observed in the FTIR-PAS spectra, particularly in the range of 1700 to 1000 cm(-1) without spectral interference from the composite. Furthermore, principal component analysis (PCA) and partial least square (PLS) regression models were applied to calibrate and validate ROX quantification. The PLS model exhibited the best performance in predicting the ROX concentration through ROX@Fe2O3/NiO samples. This proof of concept suggests that the Fe2O3/NiO nanocomposite has improved adsorption and spectral features by FTIR-PAS for sensing of organometallic compounds such as ROX. |
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1144-0546 |
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WOS:001016057200001 |
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UAI @ alexi.delcanto @ |
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1851 |
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