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Author  |
Vicuna, L.; Barrientos, E.; Norambuena, T.; Alvares, D.; Gana, J.C.; Leiva-Yamaguchi, V.; Meza, C.; Santos, J.L.; Mericq, V.; Pereira, A.; Eyheramendy, S. |
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Title |
New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry |
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2023 |
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iScience |
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iScience |
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26 |
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2 |
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106091 |
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Abstract |
Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5 – 2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P = 9.8 x 10(-9)). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Ag |
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Data Observatory |
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2589-0042 |
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WOS:000990651700001 |
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UAI @ alexi.delcanto @ |
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1808 |
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