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Author Beltran, J.F.; Nunez, E.; Nunez, F.; Silva, I.; Bravo, T.; Moffat, R.
Title Static response of asymmetrically damaged metallic strands: Experimental and numerical approach Type
Year 2018 Publication Construction And Building Materials Abbreviated Journal Constr. Build. Mater.
Volume 192 Issue Pages 538-554
Keywords Asymmetric damaged strands; Surface damage; Numerical model; Finite element simulation; Experimental test; Static capacity curve
Abstract In this study, the effect of the presence of broken wires (damage) asymmetrically distributed on metallic strands surfaces on their static response is assessed. To this end, a general mechanical model for multi layered strands is presented, in which damaged strands are treated as a 1D nonlinear beam under uncoupled biaxial bending and axial load (NLBM). The NLBM is validated by comparisons with the results obtained from an experimental program especially designed for studying the effect of surface damage distribution on strands response and 3D nonlinear finite element simulations. Analyses are carried out on two strand constructions: 1 x 7 and 1 x 19, in which the damage levels and strand diameters vary from 5% to 40% and from 3.5 mm to 22.2 mm, respectively. Results indicate that the NLBM accurate predicts the static response (residual strength, stiffness, axial strain field, and deformed configuration) of the asymmetrically damaged strands, achieving good computational efficiency and numerical robustness. (C) 2018 Elsevier Ltd. All rights reserved.
Address [Felipe Beltran, Juan] Univ Chile, Dept Civil Engn, Blanco Encalada 2002 Of 440, Santiago, Chile, Email: jbeltran@ing.uchile.cl;
Corporate Author Thesis
Publisher Elsevier Sci Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0950-0618 ISBN Medium
Area Expedition Conference
Notes WOS:000453494600046 Approved
Call Number UAI @ eduardo.moreno @ Serial 953
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Author Beltran, J.F.; Zamorano, M.; Belen, L.H.; Risopatron, J.; Valdebenito, I.; Norambuena, J.A.; Faria, J.A.; Farias, J.G.
Title A differential proteomic study reveals the downregulation of several plasma membrane Ca2+-binding proteins in the sperm of Atlantic salmon (Salmo salar) following cold storage Type
Year 2021 Publication Aquaculture Abbreviated Journal Aquaculture
Volume 545 Issue Pages 737211
Keywords Salmo salar; Motility; Proteomics; Channel; Calcium
Abstract Sperm motility is a key event in fertilization, which is regulated by different factors. Among the factors that most affect sperm motility in fish are the external concentrations of Ca2+, the influence of which is highly regulated by various plasma membrane Ca2+-binding proteins. Concentrations of this cation have also been shown to be one of the most important factors affecting motility in cold-stored sperm cells. Taking into account the aforementioned aspects, we carried out a differential proteomic study on Salmo salar sperm stored at 4 degrees C with the aim of evaluating the protein profile on day 0 and day 14. The results of our study showed that 401 proteins were significantly downregulated (p < 0.05) on day 14, where four of them are key in the sperm motility of Salmo salar. The results of this study will allow a better understanding of the sperm activation mechanisms of Salmo salar, which will be of great importance in the design of future cold storage strategies for sperm preservation.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0044-8486 ISBN Medium
Area Expedition Conference
Notes WOS:000691822000002 Approved
Call Number UAI @ alexi.delcanto @ Serial 1470
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Author Moffat, R.; Jadue, C.; Beltran, J.F.; Herrera, R.
Title Experimental evaluation of geosynthetics as reinforcement for shotcrete Type
Year 2017 Publication Geotextiles And Geomembranes Abbreviated Journal Geotext. Geomembr.
Volume 45 Issue 3 Pages 161-168
Keywords Geosynthetics; Shotcrete; Geosynthetics reinforcement; Energy absorption; Shotcrete strength
Abstract One of the commonly used stabilization systems for rock tunnels is shotcrete. This fine aggregate mortar is usually reinforced for improving its tensile and shear strength. In deep tunnels, its capacity to absorb energy has been recently considered for design purposes, as large displacements of the wall are expected. Two of the most used materials of reinforcement are steel welded-wire mesh and fibers (steel or polypropylene) in the shotcrete mix. This study presents the results and discussion of an experimental test program conducted to obtain the load-deformation curves of reinforced shotcrete, according to ASTM C 1550, using geosynthetics grids and geotextiles as alternative reinforcement materials. In addition, plain shotcrete and steel welded-wire mesh reinforced shotcrete specimens are also considered in the experimental program as benchmark cases. The experimental results are analyzed in terms of maximum strength and toughness. Results show that the use of geosynthetics as a reinforcement material is a promising alternative to obtain shotcrete with energy absorption capacity comparable with the most common reinforcement materials used. (C) 2017 Elsevier Ltd. All rights reserved.
Address [Moffat, R.] Univ Adolfo Ibanez, Dept Civil Engn, Santiago, Chile, Email: ricardo.moffat@uai.cl;
Corporate Author Thesis
Publisher Elsevier Sci Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0266-1144 ISBN Medium
Area Expedition Conference
Notes WOS:000401879300004 Approved
Call Number UAI @ eduardo.moreno @ Serial 733
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Author Zamorano, M.; Castillo, R.L.; Beltran, J.F.; Herrera, L.; Farias, J.A.; Antileo, C.; Aguilar-Gallardo, C.; Pessoa, A.; Calle, Y.; Farias, J.G.
Title Tackling Ischemic Reperfusion Injury With the Aid of Stem Cells and Tissue Engineering Type
Year 2021 Publication Frontiers in Physiology Abbreviated Journal Front. Physiol.
Volume Early Access Issue Pages
Keywords ischemia reperfusion injury, stem cells, tissue engineering, 3D culture, IRI mechanism
Abstract Ischemia is a severe condition in which blood supply, including oxygen (O), to organs and tissues is interrupted and reduced. This is usually due to a clog or blockage in the arteries that feed the affected organ. Reinstatement of blood flow is essential to salvage ischemic tissues, restoring O, and nutrient supply. However, reperfusion itself may lead to major adverse consequences. Ischemia-reperfusion injury is often prompted by the local and systemic inflammatory reaction, as well as oxidative stress, and contributes to organ and tissue damage. In addition, the duration and consecutive ischemia-reperfusion cycles are related to the severity of the damage and could lead to chronic wounds.

Clinical pathophysiological conditions associated with reperfusion events, including stroke, myocardial infarction, wounds, lung, renal, liver, and intestinal damage or failure, are concomitant in due process with a disability, morbidity, and mortality. Consequently, preventive or palliative therapies for this injury are in demand. Tissue engineering offers a promising toolset to tackle ischemia-reperfusion injuries. It devises tissue-mimetics by using the following: (1) the unique therapeutic features of stem cells, i.e., self-renewal, differentiability, anti-inflammatory, and immunosuppressants effects; (2) growth factors

to drive cell growth, and development; (3) functional biomaterials, to provide defined microarchitecture for cell-cell interactions; (4) bioprocess design tools to emulate the macroscopic environment that interacts with tissues. This strategy allows the production of cell therapeutics capable of addressing ischemia-reperfusion injury (IRI). In addition, it allows the development of physiological-tissue-mimetics to study this condition or to assess the effect of drugs. Thus, it provides a sound platform for a better understanding of the reperfusion condition. This review article presents a synopsis and discusses tissue engineering applications available to treat various types of ischemia-reperfusions,ultimately aiming to highlight possible therapies and to bring closer the gap between

preclinical and clinical settings.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1664-042X ISBN Medium
Area Expedition Conference
Notes Approved
Call Number UAI @ alexi.delcanto @ Serial 1486
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