toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
  Record Links
Author (up) Abenza, J.F.; Couturier, E.; Dodgson, J.; Dickmann, J.; Chessel, A.; Dumais, J.; Salas, R.E.C. pdf  doi
  Title Wall mechanics and exocytosis define the shape of growth domains in fission yeast Type
  Year 2015 Publication Nature Communications Abbreviated Journal Nat. Commun.  
  Volume 6 Issue Pages 13 pp  
  Abstract The amazing structural variety of cells is matched only by their functional diversity, and reflects the complex interplay between biochemical and mechanical regulation. How both regulatory layers generate specifically shaped cellular domains is not fully understood. Here, we report how cell growth domains are shaped in fission yeast. Based on quantitative analysis of cell wall expansion and elasticity, we develop a model for how mechanics and cell wall assembly interact and use it to look for factors underpinning growth domain morphogenesis. Surprisingly, we find that neither the global cell shape regulators Cdc42-Scd1-Scd2 nor the major cell wall synthesis regulators Bgs1-Bgs4-Rgf1 are reliable predictors of growth domain geometry. Instead, their geometry can be defined by cell wall mechanics and the cortical localization pattern of the exocytic factors Sec6-Syb1-Exo70. Forceful re-directioning of exocytic vesicle fusion to broader cortical areas induces proportional shape changes to growth domains, demonstrating that both features are causally linked.  
  Address [Abenza, Juan F.; Dodgson, James; Dickmann, Johanna; Chessel, Anatole; Salas, Rafael E. Carazo] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England, Email:;  
  Corporate Author Thesis  
  Publisher Nature Publishing Group Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2041-1723 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000364922900002 Approved  
  Call Number UAI @ eduardo.moreno @ Serial 553  
Permanent link to this record
Select All    Deselect All
 |   | 

Save Citations:
Export Records: