| Record |
Author  |
Vicuna, L.; Barrientos, E.; Norambuena, T.; Alvares, D.; Gana, J.C.; Leiva-Yamaguchi, V.; Meza, C.; Santos, J.L.; Mericq, V.; Pereira, A.; Eyheramendy, S. |
| Title |
New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry |
Type |
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| Year |
2023 |
Publication |
iScience |
Abbreviated Journal |
iScience |
| Volume |
26 |
Issue |
2 |
Pages |
106091 |
| Keywords |
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| Abstract |
Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5 – 2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P = 9.8 x 10(-9)). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Ag |
| Address |
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| Corporate Author |
Data Observatory |
Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
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Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2589-0042 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000990651700001 |
Approved |
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| Call Number |
UAI @ alexi.delcanto @ |
Serial |
1808 |
| Permanent link to this record |
