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Author |
Demongeot, J.; Goles, E.; Morvan, M.; Noual, M.; Sene, S. |
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Title |
Attraction Basins as Gauges of Robustness against Boundary Conditions in Biological Complex Systems |
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Year |
2010 |
Publication |
Plos One |
Abbreviated Journal |
PLoS One |
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Volume |
5 |
Issue |
8 |
Pages |
18 pp |
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Abstract |
One fundamental concept in the context of biological systems on which researches have flourished in the past decade is that of the apparent robustness of these systems, i.e., their ability to resist to perturbations or constraints induced by external or boundary elements such as electromagnetic fields acting on neural networks, micro-RNAs acting on genetic networks and even hormone flows acting both on neural and genetic networks. Recent studies have shown the importance of addressing the question of the environmental robustness of biological networks such as neural and genetic networks. In some cases, external regulatory elements can be given a relevant formal representation by assimilating them to or modeling them by boundary conditions. This article presents a generic mathematical approach to understand the influence of boundary elements on the dynamics of regulation networks, considering their attraction basins as gauges of their robustness. The application of this method on a real genetic regulation network will point out a mathematical explanation of a biological phenomenon which has only been observed experimentally until now, namely the necessity of the presence of gibberellin for the flower of the plant Arabidopsis thaliana to develop normally. |
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Address |
[Demongeot, Jacques] Univ Grenoble 1, TIMC IMAG, CNRS, UMR 5525, La Tronche, France, Email: Sylvain.Sene@ibisc.univ-evry.fr |
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Public Library Science |
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English |
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ISSN |
1932-6203 |
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WOS:000280605400002 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
92 |
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Author |
Goles, E.; Noual, M. |
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Title |
Disjunctive networks and update schedules |
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Year |
2012 |
Publication |
Advances In Applied Mathematics |
Abbreviated Journal |
Adv. Appl. Math. |
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Volume |
48 |
Issue |
5 |
Pages |
646-662 |
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Keywords |
Regulation network; Linear Boolean network; Attractor; Limit cycle; Fixed point; Update schedule |
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Abstract |
In this paper, we present a study of the dynamics of disjunctive networks under all block-sequential update schedules. We also present an extension of this study to more general fair periodic update schedules, that is, periodic update schedules that do not update some elements much more often than some others. Our main aim is to classify disjunctive networks according to the robustness of their dynamics with respect to changes of their update schedules. To study this robustness, we focus on one property, that of being able to cycle dynamically. (C) 2012 Elsevier Inc. All rights reserved. |
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Address |
[Noual, Mathilde] Univ Lyon, Lab Informat Parallelisme, ENS Lyon, CNRS UMR5668, F-69342 Lyon 07, France, Email: mathilde.noual@ens-lyon.fr |
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Academic Press Inc Elsevier Science |
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English |
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0196-8858 |
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Notes |
WOS:000304682200004 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
217 |
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