|
Records |
Links |
|
Author  |
Slane, J.; Vivanco, J.; Rose, W.; Ploeg, H.L.; Squire, M. |

|
|
Title |
Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles |
Type |
|
|
Year |
2015 |
Publication |
Materials Science & Engineering C-Materials For Biological Applications |
Abbreviated Journal |
Mater. Sci. Eng. C-Mater. Biol. Appl. |
|
|
Volume |
48 |
Issue |
|
Pages |
188-196 |
|
|
Keywords |
Bone cement; Infection; Nanoparticles; Antimicrobial; Mechanical properties |
|
|
Abstract |
Prosthetic joint infection is one of the most serious complications that can lead to failure of a total joint replacement. Recently, the rise of multidrug resistant bacteria has substantially reduced the efficacy of antibiotics that are typically incorporated into acrylic bone cement. Silver nanoparticles (AgNPs) are an attractive alternative to traditional antibiotics resulting from their broad-spectrum antimicrobial activity and low bacterial resistance. The purpose of this study, therefore, was to incorporate metallic silver nanoparticles into acrylic bone cement and quantify the effects on the cement's mechanical, material and antimicrobial properties. AgNPs at three loading ratios (025, 0.5, and 1.0% wt/wt) were incorporated into a commercial bone cement using a probe sonication technique. The resulting cements demonstrated mechanical and material properties that were not substantially different from the standard cement. Testing against Staphylococcus aureus and Staphylococcus epidermidis using Kirby-Bauer and time-kill assays demonstrated no antimicrobial activity against planktonic bacteria. In contrast, cements modified with AgNPs significantly reduced biofilm formation on the surface of the cement. These results indicate that AgNP-loaded cement is of high potential for use in primary arthroplasty where prevention of bacterial surface colonization is vital. (C) 2014 Elsevier B.V. All rights reserved. |
|
|
Address |
[Slane, Josh; Squire, Matthew] Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI USA, Email: jaslane@wisc.edu |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
0928-4931 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
WOS:000348749200025 |
Approved |
|
|
|
Call Number |
UAI @ eduardo.moreno @ |
Serial |
623 |
|
Permanent link to this record |
|
|
|
|
Author  |
Slane, J.A.; Vivanco, J.F.; Rose, W.E.; Squire, M.W.; Ploeg, H.L. |

|
|
Title |
The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement |
Type |
|
|
Year |
2014 |
Publication |
Materials Science & Engineering C-Materials For Biological Applications |
Abbreviated Journal |
Mater. Sci. Eng. C-Mater. Biol. Appl. |
|
|
Volume |
42 |
Issue |
|
Pages |
168-176 |
|
|
Keywords |
Bone cement; Infection; Drug release; Mechanical properties; Biofilm |
|
|
Abstract |
Soluble particulate fillers can be incorporated into antibiotic-loaded acrylic bone cement in an effort to enhance antibiotic elution. Xylitol is a material that shows potential for use as a filler due to its high solubility and potential to inhibit biofilm formation. The objective of this work, therefore, was to investigate the usage of low concentrations of xylitol in a gentamicin-loaded cement. Five different cements were prepared with various xylitol loadings (0, 1, 2.5, 5 or 10 g) per cement unit, and the resulting impact on the mechanical properties, cumulative antibiotic release, biofilm inhibition, and thermal characteristics were quantified. Xylitol significantly increased cement porosity and a sustained increase in gentamicin elution was observed in all samples containing xylitol with a maximum cumulative release of 41.3%. Xylitol had no significant inhibitory effect on biofilm formation. All measured mechanical properties tended to decrease with increasing xylitol concentration; however, these effects were not always significant. Polymerization characteristics were consistent among all groups with no significant differences found. The results from this study indicate that xylitol-modified bone cement may not be appropriate for implant fixation but could be used in instances where sustained, increased antibiotic elution is warranted, such as in cement spacers or beads. (C) 2014 Elsevier B.V. All rights reserved. |
|
|
Address |
[Slane, Josh A.; Ploeg, Heidi-Lynn] Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA, Email: jaslane@wisc.edu |
|
|
Corporate Author |
|
Thesis |
|
|
|
Publisher |
Elsevier Science Bv |
Place of Publication |
|
Editor |
|
|
|
Language |
English |
Summary Language |
|
Original Title |
|
|
|
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
|
Series Volume |
|
Series Issue |
|
Edition |
|
|
|
ISSN |
0928-4931 |
ISBN |
|
Medium |
|
|
|
Area |
|
Expedition |
|
Conference |
|
|
|
Notes |
WOS:000340687400024 |
Approved |
|
|
|
Call Number |
UAI @ eduardo.moreno @ |
Serial |
403 |
|
Permanent link to this record |