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Slane, J.; Vivanco, J.; Ebenstein, D.; Squire, M.; Ploeg, H.L. |
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Title |
Multiscale characterization of acrylic bone cement modified with functionalized mesoporous silica nanoparticles |
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Year |
2014 |
Publication |
Journal Of The Mechanical Behavior Of Biomedical Materials |
Abbreviated Journal |
J. Mech. Behav. Biomed. Mater. |
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Volume |
37 |
Issue |
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Pages |
141-152 |
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Keywords |
Bone cement; Mechanical properties; Nanoindentation; Reinforced polymer; Orthopedics |
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Abstract |
Acrylic bone cement is widely used to anchor orthopedic implants to bone and mechanical failure of the cement mantle surrounding an implant can contribute to aseptic loosening. In an effort to enhance the mechanical properties of bone cement, a variety of nanoparticles and fibers can be incorporated into the cement matrix. Mesoporous silica nanoparticles (MSNs) are a class of particles that display high potential for use as reinforcement within bone cement. Therefore, the purpose of this study was to quantify the impact of modifying an acrylic cement with various low-loadings of mesoporous silica. Three types of MSNs (one plain variety and two modified with functional groups) at two loading ratios (0.1 and 0.2 wt/wt) were incorporated into a commercially available bone cement. The mechanical properties were characterized using four-point bending, microindentation and nanoindentation (static, stress relaxation, and creep) while material properties were assessed through dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, FTIR spectroscopy, and scanning electron microscopy. Four-point flexural testing and nanoindentation revealed minimal impact on the properties of the cements, except for several changes in the nano-level static mechanical properties. Conversely, microindentation testing demonstrated that the addition of MSNs significantly increased the microhardness. The stress relaxation and creep properties of the cements measured with nanoindentation displayed no effect resulting from the addition of MSNs. The measured material properties were consistent among all cements. Analysis of scanning electron micrographs images revealed that surface functionalization enhanced particle dispersion within the cement matrix and resulted in fewer particle agglomerates. These results suggest that the loading ratios of mesoporous silica used in this study were not an effective reinforcement material. Future work should be conducted to determine the impact of higher MSN loading ratios and alternative functional groups. (C) 2014 Elsevier Ltd. All rights reserved. |
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[Slane, Josh; Ploeg, Heidi-Lynn] Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA, Email: jaslane@wisc.edu |
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Elsevier Science Bv |
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English |
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1751-6161 |
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WOS:000340987100015 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
404 |
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Author |
Slane, J.; Vivanco, J.; Meyer, J.; Ploeg, H.L.; Squire, M. |
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Title |
Modification of acrylic bone cement with mesoporous silica nanoparticles: Effects on mechanical, fatigue and absorption properties |
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Year |
2014 |
Publication |
Journal Of The Mechanical Behavior Of Biomedical Materials |
Abbreviated Journal |
J. Mech. Behav. Biomed. Mater. |
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Volume |
29 |
Issue |
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Pages |
451-461 |
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Keywords |
Acrylic bone cement; Fatigue; Fracture toughness; Mesoporous silica; Implant fixation |
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Abstract |
Polymethyl methacrylate bone cement is the most common and successful method used to anchor orthopedic implants to bone, as evidenced by data from long-term national joint registries. Despite these successes, mechanical failure of the cement mantle can result in premature failure of an implant which has lead to the development of a variety of techniques aimed at enhancing the mechanical properties of the cement, such as the addition of particulate or fiber reinforcements. This technique however has not transitioned into clinical practice, likely due to problems relating to interfacial particle/matrix adhesion and high cement stiffness. Mesoporous silica nanoparticles (MSNs) are a class of materials that have received little attention as polymer reinforcements despite their potential ability to overcome these challenges. Therefore, the objective of the present study was to investigate the use of mesoporous silica nanoparticles (MSNs) as a reinforcement material within acrylic bone cement. Three different MSN loading ratios (0.5%, 2% and 5% (wt/wt)) were incorporated into a commercially available bone cement and the resulting impact on the cement's static mechanical properties, fatigue life and absorption/elution properties were quantified. The flexural modulus and compressive strength and modulus tended to increase with higher MSN concentration. Conversely, the flexural strength, fracture toughness and work to fracture all significantly decreased with increasing MSN content. The fatigue properties were found to be highly influenced by MSNs, with substantial detrimental effects seen with high MSN loadings. The incorporation of 5% MSNs significantly increased cement's hydration degree and elution percentage. The obtained results suggest that the interfacial adhesion strength between the nanoparticles and the polymer matrix was poor, leading to a decrease in the flexural and fatigue properties, or that adequate dispersion of the MSNs was not achieved. These findings could potentially be mitigated in future work by chemically modifying the mesoporous silica with functional groups. (C) 2013 Elsevier Ltd. All rights reserved. |
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[Slane, Josh] Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA, Email: jaslane@wise.edu |
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Elsevier Science Bv |
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English |
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1751-6161 |
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Notes |
WOS:000330085700041 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
341 |
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Author |
Slane, J.; Vivanco, J.; Rose, W.; Ploeg, H.L.; Squire, M. |
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Title |
Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles |
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Year |
2015 |
Publication |
Materials Science & Engineering C-Materials For Biological Applications |
Abbreviated Journal |
Mater. Sci. Eng. C-Mater. Biol. Appl. |
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Volume |
48 |
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Pages |
188-196 |
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Keywords |
Bone cement; Infection; Nanoparticles; Antimicrobial; Mechanical properties |
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Abstract |
Prosthetic joint infection is one of the most serious complications that can lead to failure of a total joint replacement. Recently, the rise of multidrug resistant bacteria has substantially reduced the efficacy of antibiotics that are typically incorporated into acrylic bone cement. Silver nanoparticles (AgNPs) are an attractive alternative to traditional antibiotics resulting from their broad-spectrum antimicrobial activity and low bacterial resistance. The purpose of this study, therefore, was to incorporate metallic silver nanoparticles into acrylic bone cement and quantify the effects on the cement's mechanical, material and antimicrobial properties. AgNPs at three loading ratios (025, 0.5, and 1.0% wt/wt) were incorporated into a commercial bone cement using a probe sonication technique. The resulting cements demonstrated mechanical and material properties that were not substantially different from the standard cement. Testing against Staphylococcus aureus and Staphylococcus epidermidis using Kirby-Bauer and time-kill assays demonstrated no antimicrobial activity against planktonic bacteria. In contrast, cements modified with AgNPs significantly reduced biofilm formation on the surface of the cement. These results indicate that AgNP-loaded cement is of high potential for use in primary arthroplasty where prevention of bacterial surface colonization is vital. (C) 2014 Elsevier B.V. All rights reserved. |
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Address |
[Slane, Josh; Squire, Matthew] Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI USA, Email: jaslane@wisc.edu |
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Elsevier Science Bv |
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English |
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ISSN |
0928-4931 |
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Notes |
WOS:000348749200025 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
623 |
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Author |
Slane, J.; Vivanco, J.F.; Squire, M.; Ploeg, H.L. |
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Title |
Characterization of the quasi-static and viscoelastic properties of orthopaedic bone cement at the macro and nanoscale |
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Year |
2017 |
Publication |
Journal Of Biomedical Materials Research Part B-Applied Biomaterials |
Abbreviated Journal |
J. Biomed. Mater. Res. Part B |
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Volume |
105 |
Issue |
6 |
Pages |
1461-1468 |
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Keywords |
bone cement; nanoindentation; mechanical testing; creep; orthopaedics |
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Abstract |
Acrylic bone cement is often used in total joint replacement procedures to anchor an orthopaedic implant to bone. Bone cement is a viscoelastic material that exhibits creep and stress relaxation properties, which have been previously characterized using a variety of techniques such as flexural testing. Nanoindentation has become a popular method to characterize polymer mechanical properties at the nanoscale due to the technique's high sensitivity and the small sample volume required for testing. The purpose of the present work therefore was to determine the mechanical properties of bone cement using traditional macroscale techniques and compare the results to those obtained from nanoindentation. To this end, the quasi-static and viscoelastic properties of two commercially available cements, Palacos and Simplex, were assessed using a combination of three-point bending and nanoindentation. Quasi-static properties obtained from nanoindentation tended to be higher relative to three-point bending. The general displacement and creep compliance trends were similar for the two methods. These findings suggest that nanoindentation is an attractive characterization technique for bone cement, due to the small sample volumes required for testing. This may prove particularly useful in testing failed/ retrieved cement samples from patients where material availability is typically limited. (C) 2016 Wiley Periodicals, Inc. |
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Address |
[Slane, Josh] Katholieke Univ Leuven, Univ Hosp Leuven, Inst Orthopaed Res & Training, Pellenberg, Belgium, Email: joshua.slane@kuleuven.be |
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Wiley |
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English |
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ISSN |
1552-4973 |
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Notes |
WOS:000407055400016 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
752 |
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Author |
Slane, J.A.; Vivanco, J.F.; Rose, W.E.; Squire, M.W.; Ploeg, H.L. |
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Title |
The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement |
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Year |
2014 |
Publication |
Materials Science & Engineering C-Materials For Biological Applications |
Abbreviated Journal |
Mater. Sci. Eng. C-Mater. Biol. Appl. |
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Volume |
42 |
Issue |
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168-176 |
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Keywords |
Bone cement; Infection; Drug release; Mechanical properties; Biofilm |
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Abstract |
Soluble particulate fillers can be incorporated into antibiotic-loaded acrylic bone cement in an effort to enhance antibiotic elution. Xylitol is a material that shows potential for use as a filler due to its high solubility and potential to inhibit biofilm formation. The objective of this work, therefore, was to investigate the usage of low concentrations of xylitol in a gentamicin-loaded cement. Five different cements were prepared with various xylitol loadings (0, 1, 2.5, 5 or 10 g) per cement unit, and the resulting impact on the mechanical properties, cumulative antibiotic release, biofilm inhibition, and thermal characteristics were quantified. Xylitol significantly increased cement porosity and a sustained increase in gentamicin elution was observed in all samples containing xylitol with a maximum cumulative release of 41.3%. Xylitol had no significant inhibitory effect on biofilm formation. All measured mechanical properties tended to decrease with increasing xylitol concentration; however, these effects were not always significant. Polymerization characteristics were consistent among all groups with no significant differences found. The results from this study indicate that xylitol-modified bone cement may not be appropriate for implant fixation but could be used in instances where sustained, increased antibiotic elution is warranted, such as in cement spacers or beads. (C) 2014 Elsevier B.V. All rights reserved. |
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Address |
[Slane, Josh A.; Ploeg, Heidi-Lynn] Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA, Email: jaslane@wisc.edu |
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Thesis |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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ISSN |
0928-4931 |
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Notes |
WOS:000340687400024 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
403 |
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Author |
Vivanco, J.; Jakes, J.E.; Slane, J.; Ploeg, H.L. |
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Title |
Accounting for structural compliance in nanoindentation measurements of bioceramic bone scaffolds |
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Year |
2014 |
Publication |
Ceramics International |
Abbreviated Journal |
Ceram. Int. |
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Volume |
40 |
Issue |
8 |
Pages |
12485-12492 |
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Keywords |
Bioceramic; Bone scaffold; Nanoindentation; Musculoskeletal injuries |
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Abstract |
Structural properties have been shown to be critical in the osteoconductive capacity and strength of bioactive ceramic bone scaffolds. Given the cellular foam-like structure of bone scaffolds, nanoindentation has been used as a technique to assess the mechanical properties of individual components of the scaffolds. Nevertheless, nanoindents placed on scaffolds may violate the rigid support assumption of the standard Oliver-Pharr method currently used in evaluating the Meyer hardness, H, and elastic modulus, E-s, of such structures. Thus, the objective of this research was to use the structural compliance method to assess whether or not specimen-scale flexing may occur during nanoindentation of bioceramic bone scaffolds and to remove the associated artifact on the H and E-s if it did occur. Scaffolds were fabricated using tricalcium phosphate and sintered at 950 degrees C and 1150 degrees C, and nanoindents were placed in three different (center, edge, and corner) scaffold locations. Using only the standard Oliver-Pharr analysis it was found that H and E-s were significantly affected by both sintering temperature and nanoindents location (p < 0.05). However, specimen-scale flexing occurred during nanoindentation in the 1150 degrees C corner location. After removing the effects of the flexing from the measurement using the structural compliance method, it was concluded that H and E-s were affected only by the sintering temperature (p < 0.05) irrespective of the nanoindent locations. These results show that specimen-scale flexing may occur during nanoindentation of components in porous bioceramic scaffolds or in similar structure biomaterials, and that the structural compliance method must be utilized to accurately assess H and E-s of these components. (C) 2014 Elsevier Ltd and Techna Group S.r.l. All rights reserved. |
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Address |
[Vivanco, Juan; Slane, Josh; Ploeg, Heidi-Lynn] Univ Wisconsin, Dept Mech Engn, Madison, WI 53706 USA, Email: vivanco@wisc.edu |
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Publisher |
Elsevier Sci Ltd |
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English |
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ISSN |
0272-8842 |
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Notes |
WOS:000340328600122 |
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Call Number |
UAI @ eduardo.moreno @ |
Serial |
400 |
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