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Author Altimiras, F.; Garcia, J.A.; Palacios-Garcia, I.; Hurley, M.J.; Deacon, R.; Gonzalez, B.; Cogram, P.
Title Altered Gut Microbiota in a Fragile X Syndrome Mouse Model Type
Year 2021 Publication Frontiers in Neuroscience Abbreviated Journal Front. Neurosci.
Volume 15 Issue Pages 653120
Abstract The human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is a neurodevelopmental disorder considered the most common cause of inherited intellectual disability and the leading monogenetic cause of autism. The role of the gut microbiome in FXS remains largely unexplored. Here, we report the results of a gut microbiome analysis using a FXS mouse model and 16S ribosomal RNA gene sequencing. We identified alterations in the fmr1 KO2 gut microbiome associated with different bacterial species, including those in the genera Akkermansia, Sutterella, Allobaculum, Bifidobacterium, Odoribacter, Turicibacter, Flexispira, Bacteroides, and Oscillospira. Several gut bacterial metabolic pathways were significantly altered in fmr1 KO2 mice, including menaquinone degradation, catechol degradation, vitamin B6 biosynthesis, fatty acid biosynthesis, and nucleotide metabolism. Several of these metabolic pathways, including catechol degradation, nucleotide metabolism and fatty acid biosynthesis, were previously reported to be altered in children and adults with autism. The present study reports a potential association of the gut microbiome with FXS, thereby opening new possibilities for exploring reliable treatments and non-invasive biomarkers.
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Language Summary Language Original Title
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Series Volume Series Issue Edition
ISSN 1662-453X ISBN Medium
Area Expedition Conference
Notes WOS:000659516900001 Approved
Call Number UAI @ alexi.delcanto @ Serial 1415
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