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Author Benitez, S.; Duarte, C.; Opitz, T.; Lagos, N.A.; Pulgar, J.M.; Vargas, C.A.; Lardies, M.A.
Title Intertidal pool fish Girella laevifrons (Kyphosidae) shown strong physiological homeostasis but shy personality: The cost of living in hypercapnic habitats Type
Year 2017 Publication Marine Pollution Bulletin Abbreviated Journal Mar. Pollut. Bull.
Volume 118 Issue 1-2 Pages 57-63
Keywords Carbon dioxide; Hypercapnic conditions; Physiology; Behavior; Intertidal pool; Fish
Abstract Tide pools habitats are naturally exposed to a high degree of environmental variability. The consequences of living in these extreme habitats are not well established. In particular, little it is known about of the effects of hypercanic seawater (i.e. high pCO(2) levels) on marine vertebrates such as intertidal pool fish. The aim of this study was to evaluate the effects of increased pCO(2) on the physiology and behavior in juveniles of the intertidal pool fish Girella laevifrons. Two nominal pCO(2) concentrations (400 and 1600 patm) were used. We found that exposure to hypercapnic conditions did not affect oxygen consumption and absorption efficiency. However, the lateralization and boldness behavior was significantly disrupted in high pCO(2) conditions. In general, a predator-risk cost of boldness is assumed, thus the increased occurrence of shy personality in juvenile fishes may result in a change in the balance of this biological interaction, with significant ecological consequences. (C) 2017 Elsevier Ltd. All rights reserved.
Address [Benitez, S.; Lagos, N. A.] Univ Santo Tomos, Fac Ciencias, Ctr Invest & Innovat Cambia Climat CiiCC, Santiago, Chile, Email: cristian.duarte@unab.cl
Corporate Author Thesis
Publisher Pergamon-Elsevier Science Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0025-326x ISBN Medium
Area Expedition Conference
Notes WOS:000402217300020 Approved
Call Number UAI @ eduardo.moreno @ Serial 737
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Author Deacon, R.M.J.; Hurley, M.J.; Rebolledo, C.M.; Snape, M.; Altimiras, F.J.; Farias, L.; Pino, M.; Biekofsky, R.; Glass, L.; Cogram, P.
Title Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566 Type
Year 2017 Publication Genes Brain And Behavior Abbreviated Journal Genes Brain Behav.
Volume 16 Issue 7 Pages 1-10
Keywords Autism spectrum disorder; behavior; E-cadherin; Fmr1 knockout mouse; fragile X syndrome; GST-alpha 1; NNZ2566; NQO1; Nrf2/ARE pathway; oxidative stress
Abstract Fragile X-associated disorders are a family of genetic conditions resulting from the partial or complete loss of fragile X mental retardation protein (FMRP). Among these disorders, fragile X syndrome (FXS) is the most common cause of inherited intellectual disability and autism. Progress in basic neuroscience has led to identification of molecular targets for treatment in FXS; however, there is a gap in translation to targeted therapies in humans. This study introduces a novel therapeutic target for FXS, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor known to induce expression of over 100 cytoprotective genes. We also show that NNZ2566, a drug that has successfully completed a phase 2 clinical trial in FXS, is effective in modulating this target in FXS, partially reversing the FXS phenotype; NNZ2566 has a therapeutic role as Nrf2 activator. Effectively, treatment with NNZ2566 normalizes the translocation of Nrf2 to the nucleus, inducing expression of numerous oxidative stress-related genes including NQO1 (NAD(P) H dehydrogenase quinone 1), GST-alpha 1 (glutathione S-transferase alpha-1) and EH (epoxide hydrolase) and has a knockdown effect on E-cadherin. In summary, the Nrf2/ARE (antioxidant response element) pathway appears to be a novel promising therapeutic target for FXS and NNZ2566 appears to be acting as an activator of the Nrf2/ARE pathway and suggests a potential benefit across multiple symptoms that could be associated with the pathobiological processes underlying FXS.
Address [Deacon, R. M. J.; Altimiras, F. J.; Farias, L.; Pino, M.; Cogram, P.] Fraunhofer Res Fdn, Biomed Div, Ctr Syst Biotechnol, Santiago, Chile, Email: robertmj.deacon@gmail.com;
Corporate Author Thesis
Publisher Wiley Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1601-1848 ISBN Medium
Area Expedition Conference
Notes WOS:000410314200008 Approved
Call Number UAI @ eduardo.moreno @ Serial 861
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Author Montalva-Medel, M.; Ledger, T.; Ruz, G.A.; Goles, E.
Title Lac Operon Boolean Models: Dynamical Robustness and Alternative Improvements Type
Year 2021 Publication Mathematics Abbreviated Journal Mathematics
Volume 9 Issue 6 Pages 600
Keywords ELEMENTARY CELLULAR-AUTOMATA; CARBON CATABOLITE REPRESSION; GLUCOSE-LACTOSE DIAUXIE; ESCHERICHIA-COLI; BLOCK INVARIANCE; MAXIMUM SENSITIVITY; BETA-GALACTOSIDASE; BISTABLE BEHAVIOR; BISTABILITY; NETWORK
Abstract In Veliz-Cuba and Stigler 2011, Boolean models were proposed for the lac operon in Escherichia coli capable of reproducing the operon being OFF, ON and bistable for three (low, medium and high) and two (low and high) parameters, representing the concentration ranges of lactose and glucose, respectively. Of these 6 possible combinations of parameters, 5 produce results that match with the biological experiments of Ozbudak et al., 2004. In the remaining one, the models predict the operon being OFF while biological experiments show a bistable behavior. In this paper, we first explore the robustness of two such models in the sense of how much its attractors change against any deterministic update schedule. We prove mathematically that, in cases where there is no bistability, all the dynamics in both models lack limit cycles while, when bistability appears, one model presents 30% of its dynamics with limit cycles while the other only 23%. Secondly, we propose two alternative improvements consisting of biologically supported modifications; one in which both models match with Ozbudak et al., 2004 in all 6 combinations of parameters and, the other one, where we increase the number of parameters to 9, matching in all these cases with the biological experiments of Ozbudak et al., 2004.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes WOS:000645324300001 Approved
Call Number UAI @ alexi.delcanto @ Serial 1374
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Author Villena, M.J.; Reus, L.
Title On the strategic behavior of large investors: A mean-variance portfolio approach Type
Year 2016 Publication European Journal Of Operational Research Abbreviated Journal Eur. J. Oper. Res.
Volume 254 Issue 2 Pages 679-688
Keywords Investment analysis; Large investors; Strategic behavior; Markowitz portfolio allocation; Nash equilibrium
Abstract One key assumption of Markowitz's model is that all traders act as price takers. In this paper, we extend this mean-variance approach in a setting where large investors can move prices. Instead of having an individual optimization problem, we find the investors' Nash equilibrium and redefine the efficient frontier in this new framework. We also develop a simplified application of the general model, with two assets and two investors to shed light on the potential strategic behavior of large and atomic investors. Our findings validate the claim that large investors enhance their portfolio performance in relation to perfect market conditions. Besides, we show under which conditions atomic investors can benefit in relation to the standard setting, even if they have not total influence on their eventual performance. The 'two investors-two assets' setting allows us to quantify performance and do sensitivity analysis regarding investors' market power, risk tolerance and price elasticity of demand. Finally, for a group of well known ETFs, we empirically show how price variations change depending on the volume traded. We also explain how to set up and use our model with real market data. (C) 2016 Elsevier B.V. All rights reserved.
Address [Villena, Marcelo J.; Reus, Lorenzo] Univ Adolfo Ibanez, Fac Sci & Engn, Diagonal Torres 2640, Santiago, Chile, Email: marcelo.villena@uai.cl;
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0377-2217 ISBN Medium
Area Expedition Conference
Notes WOS:000377732300026 Approved
Call Number UAI @ eduardo.moreno @ Serial 627
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