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Author Acuna, M.; Eaton, L.; Ramirez, N.R.; Cifuentes, L.; Llop, E.
Title Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians Type
Year 2003 Publication American Journal Of Physical Anthropology Abbreviated Journal Am. J. Phys. Anthropol.
Volume 121 Issue 1 Pages 81-85
Keywords plasma butyrylcholinesterase; BCHE locus; genetic variants; Mapuche Indians
Abstract We estimated the frequencies of serum butyrylcholinesterase (BChE) alleles in three tribes of Mapuche Indians from southern Chile, using enzymatic methods, and we estimated the frequency of allele BCHE*K in one tribe using primer reduced restriction analysis (PCR-PIRA). The three tribes have different degrees of European admixture, which is reflected in the observed frequencies of the atypical allele BCHE*A: 1.11% in Huilliches, 0.89% in Cuncos, and 0% in Pehuenches. This result is evidence in favor of the hypothesis that BCHE*A is absent in native Amerindians. The frequencies of BCHE*F were higher than in most reported studies (3.89%, 5.78%, and 4.41%, respectively). These results are probably due to an overestimation of the frequency of allele BCHE*F, since none of the 20 BCHE UF individuals (by the enzymatic test) individuals analyzed showed either of the two DNA base substitutions associated with this allele. Although enzymatic methods rarely detect the presence of allele BCHE*K, PCR-PIRA found the allele in an appreciable frequency (5.76%), although lower than that found in other ethnic groups. Since observed frequencies of unusual alleles correspond to estimated percentages of European admixture, it is likely that none of these unusual alleles were present in Mapuche Indians before the arrival of Europeans. (C) 2003 Wiley-Liss, Inc.
Address Univ Santiago Chile, Fac Med, Programa Genet, ICBM, Santiago 70061 7, Chile, Email: macuna@machi.med.uchile.cl
Corporate Author Thesis
Publisher Wiley-Liss Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0002-9483 ISBN Medium
Area Expedition Conference
Notes WOS:000182336300010 Approved
Call Number UAI @ eduardo.moreno @ Serial 37
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Author Soto-Eguibar, F.; Asenjo, F.A.; Hojman, S.A.; Moya-Cessa, H.M.
Title Bohm potential for the time dependent harmonic oscillator Type
Year 2021 Publication Journal of Mathematical Physics Abbreviated Journal J. Math. Phys.
Volume 62 Issue 12 Pages 122103
Keywords SCHRODINGER-EQUATION; QUANTUM-THEORY; MASS; PROPAGATION; INVARIANTS; SYSTEMS; STATES
Abstract In the Madelung-Bohm approach to quantum mechanics, we consider a time dependent phase that depends quadratically on position, and we show that it leads to a Bohm potential that corresponds to a time dependent harmonic oscillator, provided the time dependent term in the phase obeys an Ermakov equation.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0022-2488 ISBN Medium
Area Expedition Conference
Notes WOS:000731943600003 Approved
Call Number UAI @ alexi.delcanto @ Serial 1504
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Author Vicuna, L.; Norambuena, T.; Miranda, JP.; Pereira, A.; Mericq, V.; Ongaro, L.; Montinaro, F.; Santos, JL.; Eyheramendy, S.
Title Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys Type
Year 2021 Publication Human Genetics Abbreviated Journal Hum. Genet.
Volume 140 Issue 12 Pages 1651-1661
Keywords PEAK HEIGHT VELOCITY; SECULAR TRENDS; GENOME; HEALTH; GWAS; AGE; SELECTION; VARIANTS; RESOURCE; DISEASE
Abstract Puberty is a complex developmental process that varies considerably among individuals and populations. Genetic factors explain a large proportion of the variability of several pubertal traits. Recent genome-wide association studies (GWAS) have identified hundreds of variants involved in traits that result from body growth, like adult height. However, they do not capture many genetic loci involved in growth changes over distinct growth phases. Further, such GWAS have been mostly performed in Europeans, but we do not know how these findings relate to other continental populations. In this study, we analyzed the genetic basis of three pubertal traits; namely, peak height velocity (PV), age at PV (APV) and height at APV (HAPV). We analyzed a cohort of 904 admixed Chilean children and adolescents with European and Mapuche Native American ancestries. Height was measured on roughly a 6-month basis from childhood to adolescence between 2006 and 2019. We predict that the difference in HAPV between an European and a Mapuche adolescent is 4.3 cm higher in the European (P = 0.042) and APV is 0.73 years later for the European compared with the Mapuche adolescent on average (P = 0.023). Further, by performing a GWAS on 774, 433 single-nucleotide polymorphisms, we identified a genetic signal harboring 3 linked variants significantly associated with PV in boys (P < 5 x 10(-8)). This signal has never been associated with growth-related traits.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0340-6717 ISBN Medium
Area Expedition Conference
Notes WOS:000655840600001 Approved
Call Number UAI @ alexi.delcanto @ Serial 1394
Permanent link to this record