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Author Baler, R.V.; Wijnhoven, I.B.; del Valle, V.I.; Giovanetti, C.M.; Vivanco, J.F.
Title Microporosity Clustering Assessment in Calcium Phosphate Bioceramic Particles Type
Year 2019 Publication Frontiers In Bioengineering And Biotechnology Abbreviated Journal Front. Bioeng. Biotechnol.
Volume 7 Issue 281 Pages 7 pp
Keywords calcium phosphate; bioceramic particle; microporosity; data mining; K-means clustering
Abstract There has been an increase in the application of different biomaterials to repair hard tissues. Within these biomaterials, calcium phosphate (CaP) bioceramics are suitable candidates, since they can be biocompatible, biodegradable, osteoinductive, and osteoconductive. Moreover, during sintering, bioceramic materials are prone to form micropores and undergo changes in their surface topographical features, which influence cellular physiology and bone ingrowth. In this study, five geometrical properties from the surface of CaP bioceramic particles and their micropores were analyzed by data mining techniques, driven by the research question: what are the geometrical properties of individual micropores in a CaP bioceramic, and how do they relate to each other? The analysis not only shows that it is feasible to determine the existence of micropore clusters, but also to quantify their geometrical properties. As a result, these CaP bioceramic particles present three groups of micropore clusters distinctive by their geometrical properties. Consequently, this new methodological clustering assessment can be applied to advance the knowledge about CaP bioceramics and their role in bone tissue engineering.
Address [Vallejos Baler, Raul; Irribarra del Valle, Victor; Vivanco, Juan F.] Adolfo Ibanez Univ, Fac Engn & Sci, Vina Del Mar, Chile, Email: juan.vivanco@uai.cl
Corporate Author Thesis
Publisher Frontiers Media Sa Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2296-4185 ISBN Medium
Area Expedition Conference
Notes WOS:000495370600001 Approved
Call Number UAI @ eduardo.moreno @ Serial 1062
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Author Millan, C.; Vivanco, J.F.; Benjumeda-Wijnhoven, I.M.; Bjelica, S.; Santibanez, J.F.
Title Mesenchymal Stem Cells and Calcium Phosphate Bioceramics: Implications in Periodontal Bone Regeneration Type
Year 2018 Publication Cell Biology And Translational Medicine Abbreviated Journal Adv.Exp.Med.Biol.
Volume 1107 Issue Pages 91-112
Keywords Bioceramics; Bone regeneration; Calcium phosphate; Dental; Mesenchymal stem cells; Tissue engineering
Abstract In orthopedic medicine, a feasible reconstruction of bone structures remains one of the main challenges both for healthcare and for improvement of patients' quality of life. There is a growing interest in mesenchymal stem cells (MSCs) medical application, due to their multilineage differentiation potential, and tissue engineering integration to improve bone repair and regeneration. In this review we will describe the main characteristics of MSCs, such as osteogenesis, immunomodulation and antibacterial properties, key parameters to consider during bone repair strategies. Moreover, we describe the properties of calciumphosphate (CaP) bioceramics, which demonstrate to be useful tools in combination with MSCs, due to their biocompatibility, osseointegration and osteoconduction for bone repair and regeneration. Also, we overview the main characteristics of dental cavity MSCs, which are promising candidates, in combination with CaP bioceramics, for bone regeneration and tissue engineering. The understanding of MSCs biology and their interaction with CaP bioceramics and other biomaterials is critical for orthopedic surgical bone replacement, reconstruction and regeneration, which is an integrative and dynamic medical, scientific and bioengineering field of research and biotechnology.
Address [Millan, Carola] Univ Adolfo Ibanez, Fac Artes Liberales, Fac Ingn & Ciencias, Vina Del Mar, Chile, Email: jfsantibanez@imi.bg.ac.rs
Corporate Author Thesis
Publisher Springer International Publishing Ag Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0065-2598 ISBN Medium
Area Expedition Conference
Notes WOS:000458010000007 Approved
Call Number UAI @ eduardo.moreno @ Serial 979
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