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Author Altimiras, F.; Uszczynska-Ratajczak, B.; Camara, F.; Vlasova, A.; Palumbo, E.; Newhouse, S.; Deacon, R.M.J.; Farias, L.A.E.; Hurley, M.J.; Loyola, D.E.; Vasquez, R.A.; Dobson, R.; Guigo, R.; Cogram, P.
Title Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease Type
Year 2017 Publication Frontiers In Aging Neuroscience Abbreviated Journal Front. Aging Neurosci.
Volume 9 Issue Pages 8 pp
Keywords Alzheimer's disease; Octodon degus; RNA-seq; gene expression; animal models
Abstract
Address [Altimiras, Francisco; Farias, Leandro A. E.] Univ Adolfo Ibanez, Fac Sci & Engn, Santiago, Chile, Email: fjaltimiras@gmail.com;
Corporate Author Thesis
Publisher Frontiers Media Sa Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1663-4365 ISBN Medium
Area Expedition Conference
Notes WOS:000396812400001 Approved
Call Number UAI @ eduardo.moreno @ Serial 860
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Author Lardies, M.A.; Arias, M.B.; Poupin, M.J.; Manriquez, P.H.; Torres, R.; Vargas, C.A.; Navarro, J.M.; Lagos, N.A.
Title Differential response to ocean acidification in physiological traits of Concholepas concholepas populations Type
Year 2014 Publication Journal Of Sea Research Abbreviated Journal J. Sea Res.
Volume 90 Issue Pages 127-134
Keywords Environmental gradient; Gastropod; Metabolism; HsP70; Gene expression; Phenotypic flexibility
Abstract Phenotypic adaptation to environmental fluctuations frequently occurs by preexisting plasticity and its role as a major component of variation in physiological diversity is being widely recognized. Few studies have considered the change in phenotypic flexibility among geographic populations in marine calcifiers to ocean acidification projections, despite the fact that this type of study provides understanding about how the organism may respond to this chemical change in the ocean. We examined the geographic variation in CO2 seawater concentrations in the phenotype and in the reaction norm of physiological traits using a laboratory mesocosm approach with short-term acclimation in two contrasting populations (Antofagasta and Calfuco) of the intertidal snail Concholepas concholepas. Our results show that elevated pCO(2) conditions increase standard metabolic rates in both populations of the snail juveniles, likely due to the higher energy cost of homeostasis. juveniles of C concholepas in the Calfuco (southern) population showed a lower increment of metabolic rate in high-pCO(2) environments concordant with a lesser gene expression of a heat shock protein with respect to the Antofagasta (northern) population. Combined these results indicate a negative effect of ocean acidification on whole-organism functioning of C. concholepas. Finally, the significant Population x pCO(2) level interaction in both studied traits indicates that there is variation between populations in response to high-pCO(2) conditions. (C) 2014 Elsevier BM. All rights reserved.
Address [Lardies, Marco A.; Belen Arias, Maria] Univ Adolfo Ibanez, Fac Artes Liberles, Santiago, Chile, Email: marco.lardies@ual.cl
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1385-1101 ISBN Medium
Area Expedition Conference
Notes WOS:000337854800013 Approved
Call Number UAI @ eduardo.moreno @ Serial 381
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