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Author Baler, R.V.; Wijnhoven, I.B.; del Valle, V.I.; Giovanetti, C.M.; Vivanco, J.F.
Title Microporosity Clustering Assessment in Calcium Phosphate Bioceramic Particles Type
Year 2019 Publication Frontiers In Bioengineering And Biotechnology Abbreviated Journal (up) Front. Bioeng. Biotechnol.
Volume 7 Issue 281 Pages 7 pp
Keywords calcium phosphate; bioceramic particle; microporosity; data mining; K-means clustering
Abstract There has been an increase in the application of different biomaterials to repair hard tissues. Within these biomaterials, calcium phosphate (CaP) bioceramics are suitable candidates, since they can be biocompatible, biodegradable, osteoinductive, and osteoconductive. Moreover, during sintering, bioceramic materials are prone to form micropores and undergo changes in their surface topographical features, which influence cellular physiology and bone ingrowth. In this study, five geometrical properties from the surface of CaP bioceramic particles and their micropores were analyzed by data mining techniques, driven by the research question: what are the geometrical properties of individual micropores in a CaP bioceramic, and how do they relate to each other? The analysis not only shows that it is feasible to determine the existence of micropore clusters, but also to quantify their geometrical properties. As a result, these CaP bioceramic particles present three groups of micropore clusters distinctive by their geometrical properties. Consequently, this new methodological clustering assessment can be applied to advance the knowledge about CaP bioceramics and their role in bone tissue engineering.
Address [Vallejos Baler, Raul; Irribarra del Valle, Victor; Vivanco, Juan F.] Adolfo Ibanez Univ, Fac Engn & Sci, Vina Del Mar, Chile, Email: juan.vivanco@uai.cl
Corporate Author Thesis
Publisher Frontiers Media Sa Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2296-4185 ISBN Medium
Area Expedition Conference
Notes WOS:000495370600001 Approved
Call Number UAI @ eduardo.moreno @ Serial 1062
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