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Author Baler, R.V.; Wijnhoven, I.B.; del Valle, V.I.; Giovanetti, C.M.; Vivanco, J.F. pdf  doi
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  Title Microporosity Clustering Assessment in Calcium Phosphate Bioceramic Particles Type Journal Article
  Year 2019 Publication Frontiers In Bioengineering And Biotechnology Abbreviated Journal Front. Bioeng. Biotechnol.  
  Volume 7 Issue 281 Pages 7 pp  
  Keywords calcium phosphate; bioceramic particle; microporosity; data mining; K-means clustering  
  Abstract There has been an increase in the application of different biomaterials to repair hard tissues. Within these biomaterials, calcium phosphate (CaP) bioceramics are suitable candidates, since they can be biocompatible, biodegradable, osteoinductive, and osteoconductive. Moreover, during sintering, bioceramic materials are prone to form micropores and undergo changes in their surface topographical features, which influence cellular physiology and bone ingrowth. In this study, five geometrical properties from the surface of CaP bioceramic particles and their micropores were analyzed by data mining techniques, driven by the research question: what are the geometrical properties of individual micropores in a CaP bioceramic, and how do they relate to each other? The analysis not only shows that it is feasible to determine the existence of micropore clusters, but also to quantify their geometrical properties. As a result, these CaP bioceramic particles present three groups of micropore clusters distinctive by their geometrical properties. Consequently, this new methodological clustering assessment can be applied to advance the knowledge about CaP bioceramics and their role in bone tissue engineering.  
  Address [Vallejos Baler, Raul; Irribarra del Valle, Victor; Vivanco, Juan F.] Adolfo Ibanez Univ, Fac Engn & Sci, Vina Del Mar, Chile, Email: juan.vivanco@uai.cl  
  Corporate Author Thesis  
  Publisher Frontiers Media Sa Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2296-4185 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000495370600001 Approved no  
  Call Number UAI @ eduardo.moreno @ Serial 1062  
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