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Author Cardenas, C.; Guzman, F.; Carmona, M.; Munoz, C.; Nilo, L.; Labra, A.; Marshall, S.H.
Title Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon Type
Year 2020 Publication Pathogens Abbreviated Journal Pathogens
Volume 9 Issue 8 Pages 600
Keywords interfering peptides; viral treatment; RNA fish virusesViral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies available for either. In this context, antiviral peptides emerge as effective and relatively safe therapeutic molecules. Based on in silico analysis of VP2 protein from IPNV and the RNA-dependent RNA polymerase from ISAV, a set of peptides was designed and were chemically synthesized to block selected key events in their corresponding infectivity processes. The peptides were tested in fish cell lines in vitro, and four were selected for decreasing the viral load: peptide GIM182 for IPNV, and peptides GIM535, GIM538 and GIM539 for ISAV. In vivo tests with the IPNV GIM 182 peptide were carried out using Salmo salar fish, showing a significant decrease of viral load, and proving the safety of the peptide for fish. The results indicate that the use of peptides as antiviral agents in disease control might be a viable alternative to explore in aquaculture.
Abstract Viral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies available for either. In this context, antiviral peptides emerge as effective and relatively safe therapeutic molecules. Based on in silico analysis of VP2 protein from IPNV and the RNA-dependent RNA polymerase from ISAV, a set of peptides was designed and were chemically synthesized to block selected key events in their corresponding infectivity processes. The peptides were tested in fish cell lines in vitro, and four were selected for decreasing the viral load: peptide GIM182 for IPNV, and peptides GIM535, GIM538 and GIM539 for ISAV. In vivo tests with the IPNV GIM 182 peptide were carried out using Salmo salar fish, showing a significant decrease of viral load, and proving the safety of the peptide for fish. The results indicate that the use of peptides as antiviral agents in disease control might be a viable alternative to explore in aquaculture.`
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2076-0817 ISBN Medium
Area Expedition Conference
Notes Approved
Call Number UAI @ eduardo.moreno @ Serial 1177
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Author Towers, S.; Vogt Geisse, K.; Zheng, Y.; Feng, Z.
Title Antiviral treatment for pandemic influenza: Assessing potential repercussions using a seasonally forced SIR model Type
Year 2011 Publication Journal Of Theoretical Biology Abbreviated Journal J. Theor. Biol.
Volume 289 Issue Pages 259-268
Keywords Epidemic model; Seasonally forced transmission; Antiviral treatment model; Epidemic size; Pandemic influenza model
Abstract When resources are limited, measures to control an incipient influenza pandemic must be carefully considered. Because several months are needed to mass-produce vaccines once a new pandemic strain has been identified, antiviral drugs are often considered the first line of defense in a pandemic situation. Here we use an SIR disease model with periodic transmission rate to assess the efficacy of control strategies via antiviral drug treatment during an outbreak of pandemic influenza. We show that in some situations, and independent of drug-resistance effects, antiviral treatment can have a detrimental impact on the final size of the pandemic. Antiviral treatment also has the potential to increase the size of the major peak of the pandemic, and cause it to occur earlier than it would have if treatment were not used. Our studies suggest that when a disease exhibits periodic patterns in transmission, decisions of public health policy will be particularly important as to how control measures such as drug treatment should be implemented, and to what end (i.e.; towards immediate control of a current epidemic peak, or towards potential delay and/or reduction of an anticipated autumn peak). (C) 2011 Elsevier Ltd. All rights reserved.
Address [Towers, S.; Vogt Geisse, K.; Zheng, Y.; Feng, Z.] Purdue Univ, Dept Math, W Lafayette, IN 47907 USA, Email: stowers@purdue.edu
Corporate Author Thesis
Publisher Academic Press Ltd- Elsevier Science Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-5193 ISBN Medium
Area Expedition Conference
Notes WOS:000296222800026 Approved
Call Number UAI @ eduardo.moreno @ Serial 182
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