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Author (up) Travisany, D.; Goles, E.; Latorre, M.; Cort?s, M.P.; Maass, A. doi  openurl
  Title Generation and robustness of Boolean networks to model Clostridium difficile infection Type Journal Article
  Year 2020 Publication Natural Computing Abbreviated Journal Nat. Comput.  
  Volume 19 Issue 1 Pages 111-134  
  Keywords Threshold network; Neutral space; Evolutionary computation; Microbiome; Clostridium difficile infection  
  Abstract One of the more common healthcare associated infection is Chronic diarrhea. This disease is caused by the bacterium Clostridium difficile which alters the normal composition of the human gut flora. The most successful therapy against this infection is the fecal microbial transplant (FMT). They displace C. difficile and contribute to gut microbiome resilience, stability and prevent further episodes of diarrhea. The microorganisms in the FMT their interactions and inner dynamics reshape the gut microbiome to a healthy state. Even though microbial interactions play a key role in the development of the disease, currently, little is known about their dynamics and properties. In this context, a Boolean network model for C. difficile infection (CDI) describing one set of possible interactions was recently presented. To further explore the space of possible microbial interactions, we propose the construction of a neutral space conformed by a set of models that differ in their interactions, but share the final community states of the gut microbiome under antibiotic perturbation and CDI. To begin with the analysis, we use the previously described Boolean network model and we demonstrate that this model is in fact a threshold Boolean network (TBN). Once the TBN model is set, we generate and use an evolutionary algorithm to explore to identify alternative TBNs. We organize the resulting TBNs into clusters that share similar dynamic behaviors. For each cluster, the associated neutral graph is constructed and the most relevant interactions are identified. Finally, we discuss how these interactions can either affect or prevent CDI.  
  Address [Travisany, Dante; Goles, Eric] Univers Adolfo Ibanez, Facultad Ingn Ciencias, Santiago, Chile, Email: dtravisany@dim.uchile.cl  
  Corporate Author Thesis  
  Publisher Springer Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1567-7818 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000517129300008 Approved no  
  Call Number UAI @ eduardo.moreno @ Serial 1167  
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