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Author (up) Goles, E.; Montalva, M.; Ruz, G.A. pdf  doi
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  Title Deconstruction and Dynamical Robustness of Regulatory Networks: Application to the Yeast Cell Cycle Networks Type Journal Article
  Year 2013 Publication Bulletin Of Mathematical Biology Abbreviated Journal Bull. Math. Biol.  
  Volume 75 Issue 6 Pages 939-966  
  Keywords Boolean networks; Attractors; Update robustness; Alliances; Dynamics  
  Abstract Analyzing all the deterministic dynamics of a Boolean regulatory network is a difficult problem since it grows exponentially with the number of nodes. In this paper, we present mathematical and computational tools for analyzing the complete deterministic dynamics of Boolean regulatory networks. For this, the notion of alliance is introduced, which is a subconfiguration of states that remains fixed regardless of the values of the other nodes. Also, equivalent classes are considered, which are sets of updating schedules which have the same dynamics. Using these techniques, we analyze two yeast cell cycle models. Results show the effectiveness of the proposed tools for analyzing update robustness as well as the discovery of new information related to the attractors of the yeast cell cycle models considering all the possible deterministic dynamics, which previously have only been studied considering the parallel updating scheme.  
  Address [Goles, Eric; Montalva, Marco; Ruz, Gonzalo A.] Univ Adolfo Ibanez, Fac Ingn & Ciencias, Santiago, Chile, Email: eric.chacc@uai.cl;  
  Corporate Author Thesis  
  Publisher Springer Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0092-8240 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000321220400005 Approved no  
  Call Number UAI @ eduardo.moreno @ Serial 288  
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