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Author (up) Aracena, J.; Goles, E.; Moreira, A.; Salinas, L. pdf  doi
  Title On the robustness of update schedules in Boolean networks Type
  Year 2009 Publication Biosystems Abbreviated Journal Biosystems  
  Volume 97 Issue 1 Pages 1-8  
  Keywords Boolean network; Update schedule; Robustness; Attractor; Dynamical cycle  
  Abstract Deterministic Boolean networks have been used as models of gene regulation and other biological networks. One key element in these models is the update schedule, which indicates the order in which states are to be updated. We study the robustness of the dynamical behavior of a Boolean network with respect to different update schedules (synchronous, block-sequential, sequential), which can provide modelers with a better understanding of the consequences of changes in this aspect of the model. For a given Boolean network, we define equivalence classes of update schedules with the same dynamical behavior, introducing a labeled graph which helps to understand the dependence of the dynamics with respect to the update, and to identify interactions whose timing may be crucial for the presence of a particular attractor of the system. Several other results on the robustness of update schedules and of dynamical cycles with respect to update schedules are presented. Finally, we prove that our equivalence classes generalize those found in sequential dynamical systems. (C) 2009 Elsevier Ireland Ltd. All rights reserved.  
  Address [Aracena, J.] Univ Concepcion, Dept Ingn Matemat, Concepcion, Chile, Email:  
  Corporate Author Thesis  
  Publisher Elsevier Sci Ltd Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0303-2647 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000267528900001 Approved  
  Call Number UAI @ eduardo.moreno @ Serial 29  
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