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Author Slane, J.A.; Vivanco, J.F.; Rose, W.E.; Squire, M.W.; Ploeg, H.L. pdf  doi
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  Title The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement Type Journal Article
  Year 2014 Publication Materials Science & Engineering C-Materials For Biological Applications Abbreviated Journal Mater. Sci. Eng. C-Mater. Biol. Appl.  
  Volume (down) 42 Issue Pages 168-176  
  Keywords Bone cement; Infection; Drug release; Mechanical properties; Biofilm  
  Abstract Soluble particulate fillers can be incorporated into antibiotic-loaded acrylic bone cement in an effort to enhance antibiotic elution. Xylitol is a material that shows potential for use as a filler due to its high solubility and potential to inhibit biofilm formation. The objective of this work, therefore, was to investigate the usage of low concentrations of xylitol in a gentamicin-loaded cement. Five different cements were prepared with various xylitol loadings (0, 1, 2.5, 5 or 10 g) per cement unit, and the resulting impact on the mechanical properties, cumulative antibiotic release, biofilm inhibition, and thermal characteristics were quantified. Xylitol significantly increased cement porosity and a sustained increase in gentamicin elution was observed in all samples containing xylitol with a maximum cumulative release of 41.3%. Xylitol had no significant inhibitory effect on biofilm formation. All measured mechanical properties tended to decrease with increasing xylitol concentration; however, these effects were not always significant. Polymerization characteristics were consistent among all groups with no significant differences found. The results from this study indicate that xylitol-modified bone cement may not be appropriate for implant fixation but could be used in instances where sustained, increased antibiotic elution is warranted, such as in cement spacers or beads. (C) 2014 Elsevier B.V. All rights reserved.  
  Address [Slane, Josh A.; Ploeg, Heidi-Lynn] Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA, Email: jaslane@wisc.edu  
  Corporate Author Thesis  
  Publisher Elsevier Science Bv Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0928-4931 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000340687400024 Approved no  
  Call Number UAI @ eduardo.moreno @ Serial 403  
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