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Author (up) Slane, J.; Vivanco, J.; Ebenstein, D.; Squire, M.; Ploeg, H.L. pdf  doi
  Title Multiscale characterization of acrylic bone cement modified with functionalized mesoporous silica nanoparticles Type
  Year 2014 Publication Journal Of The Mechanical Behavior Of Biomedical Materials Abbreviated Journal J. Mech. Behav. Biomed. Mater.  
  Volume 37 Issue Pages 141-152  
  Keywords Bone cement; Mechanical properties; Nanoindentation; Reinforced polymer; Orthopedics  
  Abstract Acrylic bone cement is widely used to anchor orthopedic implants to bone and mechanical failure of the cement mantle surrounding an implant can contribute to aseptic loosening. In an effort to enhance the mechanical properties of bone cement, a variety of nanoparticles and fibers can be incorporated into the cement matrix. Mesoporous silica nanoparticles (MSNs) are a class of particles that display high potential for use as reinforcement within bone cement. Therefore, the purpose of this study was to quantify the impact of modifying an acrylic cement with various low-loadings of mesoporous silica. Three types of MSNs (one plain variety and two modified with functional groups) at two loading ratios (0.1 and 0.2 wt/wt) were incorporated into a commercially available bone cement. The mechanical properties were characterized using four-point bending, microindentation and nanoindentation (static, stress relaxation, and creep) while material properties were assessed through dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, FTIR spectroscopy, and scanning electron microscopy. Four-point flexural testing and nanoindentation revealed minimal impact on the properties of the cements, except for several changes in the nano-level static mechanical properties. Conversely, microindentation testing demonstrated that the addition of MSNs significantly increased the microhardness. The stress relaxation and creep properties of the cements measured with nanoindentation displayed no effect resulting from the addition of MSNs. The measured material properties were consistent among all cements. Analysis of scanning electron micrographs images revealed that surface functionalization enhanced particle dispersion within the cement matrix and resulted in fewer particle agglomerates. These results suggest that the loading ratios of mesoporous silica used in this study were not an effective reinforcement material. Future work should be conducted to determine the impact of higher MSN loading ratios and alternative functional groups. (C) 2014 Elsevier Ltd. All rights reserved.  
  Address [Slane, Josh; Ploeg, Heidi-Lynn] Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA, Email:  
  Corporate Author Thesis  
  Publisher Elsevier Science Bv Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1751-6161 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000340987100015 Approved  
  Call Number UAI @ eduardo.moreno @ Serial 404  
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