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Author Slane, J.; Vivanco, J.; Rose, W.; Ploeg, H.L.; Squire, M. pdf  doi
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  Title Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles Type Journal Article
  Year 2015 Publication Materials Science & Engineering C-Materials For Biological Applications Abbreviated Journal Mater. Sci. Eng. C-Mater. Biol. Appl.  
  Volume 48 Issue Pages 188-196  
  Keywords Bone cement; Infection; Nanoparticles; Antimicrobial; Mechanical properties  
  Abstract Prosthetic joint infection is one of the most serious complications that can lead to failure of a total joint replacement. Recently, the rise of multidrug resistant bacteria has substantially reduced the efficacy of antibiotics that are typically incorporated into acrylic bone cement. Silver nanoparticles (AgNPs) are an attractive alternative to traditional antibiotics resulting from their broad-spectrum antimicrobial activity and low bacterial resistance. The purpose of this study, therefore, was to incorporate metallic silver nanoparticles into acrylic bone cement and quantify the effects on the cement's mechanical, material and antimicrobial properties. AgNPs at three loading ratios (025, 0.5, and 1.0% wt/wt) were incorporated into a commercial bone cement using a probe sonication technique. The resulting cements demonstrated mechanical and material properties that were not substantially different from the standard cement. Testing against Staphylococcus aureus and Staphylococcus epidermidis using Kirby-Bauer and time-kill assays demonstrated no antimicrobial activity against planktonic bacteria. In contrast, cements modified with AgNPs significantly reduced biofilm formation on the surface of the cement. These results indicate that AgNP-loaded cement is of high potential for use in primary arthroplasty where prevention of bacterial surface colonization is vital. (C) 2014 Elsevier B.V. All rights reserved.  
  Address (up) [Slane, Josh; Squire, Matthew] Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI USA, Email: jaslane@wisc.edu  
  Corporate Author Thesis  
  Publisher Elsevier Science Bv Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0928-4931 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000348749200025 Approved no  
  Call Number UAI @ eduardo.moreno @ Serial 623  
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