
Aracena, J., Demongeot, J., Fanchon, E., & Montalva, M. (2013). On the number of different dynamics in Boolean networks with deterministic update schedules. Math. Biosci., 242(2), 188–194.
Abstract: Deterministic Boolean networks are a type of discrete dynamical systems widely used in the modeling of genetic networks. The dynamics of such systems is characterized by the local activation functions and the update schedule, i.e., the order in which the nodes are updated. In this paper, we address the problem of knowing the different dynamics of a Boolean network when the update schedule is changed. We begin by proving that the problem of the existence of a pair of update schedules with different dynamics is NPcomplete. However, we show that certain structural properties of the interaction digraph are sufficient for guaranteeing distinct dynamics of a network. In [1] the authors define equivalence classes which have the property that all the update schedules of a given class yield the same dynamics. In order to determine the dynamics associated to a network, we develop an algorithm to efficiently enumerate the above equivalence classes by selecting a representative update schedule for each class with a minimum number of blocks. Finally, we run this algorithm on the well known Arabidopsis thaliana network to determine the full spectrum of its different dynamics. (C) 2013 Elsevier Inc. All rights reserved.



Aracena, J., Demongeot, J., Fanchon, E., & Montalva, M. (2013). On the number of update digraphs and its relation with the feedback arc sets and tournaments. Discret Appl. Math., 161(1011), 1345–1355.
Abstract: An update digraph corresponds to a labeled digraph that indicates a relative order of its nodes introduced to define equivalence classes of deterministic update schedules yielding the same dynamical behavior of a Boolean network. In Aracena et al. [1], the authors exhibited relationships between update digraphs and the feedback arc sets of a given digraph G. In this paper, we delve into the study of these relations. Specifically, we show differences and similarities between both sets through increasing and decreasing monotony properties in terms of their structural characteristics. Besides, we prove that these sets are equivalent if and only if all the digraph circuits are cycles. On the other hand, we characterize the minimal feedback arc sets of a given digraph in terms of their associated update digraphs. In particular, for complete digraphs, this characterization shows a close relation with acyclic tournaments. For the latter, we show that the size of the associated equivalence classes is a power of two. Finally, we determine exactly the number of update digraphs associated to digraphs containing a tournament. (C) 2013 Elsevier B.V. All rights reserved.



Demongeot, J., Goles, E., Morvan, M., Noual, M., & Sene, S. (2010). Attraction Basins as Gauges of Robustness against Boundary Conditions in Biological Complex Systems. PLoS One, 5(8), 18 pp.
Abstract: One fundamental concept in the context of biological systems on which researches have flourished in the past decade is that of the apparent robustness of these systems, i.e., their ability to resist to perturbations or constraints induced by external or boundary elements such as electromagnetic fields acting on neural networks, microRNAs acting on genetic networks and even hormone flows acting both on neural and genetic networks. Recent studies have shown the importance of addressing the question of the environmental robustness of biological networks such as neural and genetic networks. In some cases, external regulatory elements can be given a relevant formal representation by assimilating them to or modeling them by boundary conditions. This article presents a generic mathematical approach to understand the influence of boundary elements on the dynamics of regulation networks, considering their attraction basins as gauges of their robustness. The application of this method on a real genetic regulation network will point out a mathematical explanation of a biological phenomenon which has only been observed experimentally until now, namely the necessity of the presence of gibberellin for the flower of the plant Arabidopsis thaliana to develop normally.

