Abstract: The regional impact of climate change on heating and cooling demand is important to consider when designing optimal long-term energy policies. Several studies have addressed this issue, but either at a very aggregated level or without optimizing the whole energy system. The aims of this paper are to fill this gap in a generic way and to assess the impact of climate change on heating and cooling energy demands for residential and commercial sectors at the regional and nodal levels in the context of Chile's energy transition. We propose a methodology based on high resolution climate simulations for the Representative Concentration Pathways (RCP) RCP 2.6 and RCP 8.5 scenarios. First, a statistical analysis is performed to estimate the long-term trends of so-called heating and cooling degree-days and their impact on final regional energy demands. Then, demand pathways in the energy transition are assessed using a multi-sectoral energy planning model. Numerical experiments using data from Chile show an overall positive economic impact of climate change (limited to heating and cooling demands) for the energy system, with a significant decrease in heating demand compared to a limited increase in cooling requirements. For the RCP 8.5 scenario, cost reductions reach 2.1% of the total discounted system cost on the 2020-2050 period mainly due to a significant decrease of gas consumption for heating. This research highlights the importance for policymakers to consider climate change in efficient energy policies.