Abstract: In this paper we implement a long-term multi-sectoral energy planning model to evaluate the role of green hydrogen in the energy mix of Chile, a country with a high renewable potential, under stringent emission reduction objectives in 2050. Our results show that green hydrogen is a cost-effective and environmentally friendly route especially for hard-to-abate sectors, such as interprovincial and freight transport. They also suggest a strong synergy of hydrogen with electricity generation from renewable sources. Our numerical simulations show that Chile should (i) start immediately to develop hydrogen production through electrolyzers all along the country, (ii) keep investing in wind and solar generation capacities ensuring a low cost hydrogen production and reinforce the power transmission grid to allow nodal hydrogen production, (iii) foster the use of electric mobility for cars and local buses and of hydrogen for long-haul trucks and interprovincial buses and, (iv) develop seasonal hydrogen storage and hydrogen cells to be exploited for electricity supply, especially for the most stringent emission reduction objectives.