Abstract: Hot Jupiters-short-period giant planets-were the first extrasolar planets to be discovered, but many questions about their origin remain. NASA's Transiting Exoplanet Survey Satellite (TESS), an all-sky search for transiting planets, presents an opportunity to address these questions by constructing a uniform sample of hot Jupiters for demographic study through new detections and unifying the work of previous ground-based transit surveys. As the first results of an effort to build this large sample of planets, we report here the discovery of 10 new hot Jupiters (TOI-2193A b, TOI-2207b, TOI-2236b, TOI-2421b, TOI-2567b, TOI-2570b, TOI-3331b, TOI-3540A b, TOI-3693b, TOI-4137b). All of the planets were identified as planet candidates based on periodic flux dips observed by TESS, and were subsequently confirmed using ground-based time-series photometry, high-angular-resolution imaging, and high-resolution spectroscopy coordinated with the TESS Follow-up Observing Program. The 10 newly discovered planets orbit relatively bright F and G stars (G < 12.5, T (eff) between 4800 and 6200 K). The planets' orbital periods range from 2 to 10 days, and their masses range from 0.2 to 2.2 Jupiter masses. TOI-2421b is notable for being a Saturn-mass planet and TOI-2567b for being a “sub-Saturn,” with masses of 0.322 +/- 0.073 and 0.195 +/- 0.030 Jupiter masses, respectively. We also measured a detectably eccentric orbit (e = 0.17 +/- 0.05) for TOI-2207b, a planet on an 8 day orbit, while placing an upper limit of e < 0.052 for TOI-3693b, which has a 9 day orbital period. The 10 planets described here represent an important step toward using TESS to create a large and statistically useful sample of hot Jupiters.