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Acuna, M., Eaton, L., Ramirez, N. R., Cifuentes, L., & Llop, E. (2003). Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians. Am. J. Phys. Anthropol., 121(1), 81–85.
Abstract: We estimated the frequencies of serum butyrylcholinesterase (BChE) alleles in three tribes of Mapuche Indians from southern Chile, using enzymatic methods, and we estimated the frequency of allele BCHE*K in one tribe using primer reduced restriction analysis (PCR-PIRA). The three tribes have different degrees of European admixture, which is reflected in the observed frequencies of the atypical allele BCHE*A: 1.11% in Huilliches, 0.89% in Cuncos, and 0% in Pehuenches. This result is evidence in favor of the hypothesis that BCHE*A is absent in native Amerindians. The frequencies of BCHE*F were higher than in most reported studies (3.89%, 5.78%, and 4.41%, respectively). These results are probably due to an overestimation of the frequency of allele BCHE*F, since none of the 20 BCHE UF individuals (by the enzymatic test) individuals analyzed showed either of the two DNA base substitutions associated with this allele. Although enzymatic methods rarely detect the presence of allele BCHE*K, PCR-PIRA found the allele in an appreciable frequency (5.76%), although lower than that found in other ethnic groups. Since observed frequencies of unusual alleles correspond to estimated percentages of European admixture, it is likely that none of these unusual alleles were present in Mapuche Indians before the arrival of Europeans. (C) 2003 Wiley-Liss, Inc.
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Ahrer, E. M., Alderson, L., Batalha, N. M., Batalha, N. E., Bean, J. L., Beatty, T. G., et al. (2023). Identification of carbon dioxide in an exoplanet atmosphere. Nature, Early Access.
Abstract: Carbon dioxide (CO2) is a key chemical species that is found in a wide range of planetary atmospheres. In the context of exoplanets, CO2 is an indicator of the metal enrichment (that is, elements heavier than helium, also called 'metallicity')(1-3), and thus the formation processes of the primary atmospheres of hot gas giants(4-6). It is also one of the most promising species to detect in the secondary atmospheres of terrestrial exoplanets(7-9). Previous photometric measurements of transiting planets with the Spitzer Space Telescope have given hints of the presence of CO2, but have not yielded definitive detections owing to the lack of unambiguous spectroscopic identification(10-12). Here we present the detection of CO2 in the atmosphere of the gas giant exoplanet WASP-39b from transmission spectroscopy observations obtained with JWST as part of the Early Release Science programme(13,14). The data used in this study span 3.0-5.5micrometres in wavelength and show a prominent CO2 absorption feature at 4.3micrometres (26-sigma significance). The overall spectrum is well matched by one-dimensional, ten-times solar metallicity models that assume radiative-convective-thermochemical equilibrium and have moderate cloud opacity. These models predict that the atmosphere should have water, carbon monoxide and hydrogen sulfide in addition to CO2, but little methane. Furthermore, we also tentatively detect a small absorption feature near 4.0micrometres that is not reproduced by these models.
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Akhmediev, N., Kibler, B., Baronio, F., Belic, M., Zhong, W. P., Zhang, Y. Q., et al. (2016). Roadmap on optical rogue waves and extreme events. J. Opt., 18(6), 37 pp.
Abstract: The pioneering paper 'Optical rogue waves' by Solli et al (2007 Nature 450 1054) started the new subfield in optics. This work launched a great deal of activity on this novel subject. As a result, the initial concept has expanded and has been enriched by new ideas. Various approaches have been suggested since then. A fresh look at the older results and new discoveries has been undertaken, stimulated by the concept of 'optical rogue waves'. Presently, there may not by a unique view on how this new scientific term should be used and developed. There is nothing surprising when the opinion of the experts diverge in any new field of research. After all, rogue waves may appear for a multiplicity of reasons and not necessarily only in optical fibers and not only in the process of supercontinuum generation. We know by now that rogue waves may be generated by lasers, appear in wide aperture cavities, in plasmas and in a variety of other optical systems. Theorists, in turn, have suggested many other situations when rogue waves may be observed. The strict definition of a rogue wave is still an open question. For example, it has been suggested that it is defined as 'an optical pulse whose amplitude or intensity is much higher than that of the surrounding pulses'. This definition (as suggested by a peer reviewer) is clear at the intuitive level and can be easily extended to the case of spatial beams although additional clarifications are still needed. An extended definition has been presented earlier by N Akhmediev and E Pelinovsky (2010 Eur. Phys. J. Spec. Top. 185 1-4). Discussions along these lines are always useful and all new approaches stimulate research and encourage discoveries of new phenomena. Despite the potentially existing disagreements, the scientific terms 'optical rogue waves' and 'extreme events' do exist. Therefore coordination of our efforts in either unifying the concept or in introducing alternative definitions must be continued. From this point of view, a number of the scientists who work in this area of research have come together to present their research in a single review article that will greatly benefit all interested parties of this research direction. Whether the authors of this 'roadmap' have similar views or different from the original concept, the potential reader of the review will enrich their knowledge by encountering most of the existing views on the subject. Previously, a special issue on optical rogue waves (2013 J. Opt. 15 060201) was successful in achieving this goal but over two years have passed and more material has been published in this quickly emerging subject. Thus, it is time for a roadmap that may stimulate and encourage further research.
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Akian, M., Gaubert, S., & Hochart, A. (2020). A Game Theory Approach To The Existence And Uniqueness Of Nonlinear Perron-Frobenius Eigenvectors. Discret. Contin. Dyn. Syst., 40(1), 207–231.
Abstract: We establish a generalized Perron-Frobenius theorem, based on a combinatorial criterion which entails the existence of an eigenvector for any nonlinear order-preserving and positively homogeneous map f acting on the open orthant R->0(n). This criterion involves dominions, i.e., sets of states that can be made invariant by one player in a two-person game that only depends on the behavior of f “at infinity”. In this way, we characterize the situation in which for all alpha, beta > 0, the “slice space” S-alpha(beta) :={x is an element of R->0(n) vertical bar alpha x <= f(x) <= beta x} is bounded in Hilbert's projective metric, or, equivalently, for all uniform perturbations g of f, all the orbits of g are bounded in Hilbert's projective metric. This solves a problem raised by Gaubert and Gunawardena (Trans. AMS, 2004). We also show that the uniqueness of an eigenvector is characterized by a dominion condition, involving a different game depending now on the local behavior of f near an eigenvector. We show that the dominion conditions can be verified by directed hypergraph methods. We finally illustrate these results by considering specific classes of nonlinear maps, including Shapley operators, generalized means and nonnegative tensors.
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Alvarez-Miranda, E., & Pereira, J. (2019). On the complexity of assembly line balancing problems. Comput. Oper. Res., 108, 182–186.
Abstract: Assembly line balancing is a family of combinatorial optimization problems that has been widely studied in the literature due to its simplicity and industrial applicability. Most line balancing problems are NP-hard as they subsume the bin packing problem as a special case. Nevertheless, it is common in the line balancing literature to cite [A. Gutjahr and G. Nemhauser, An algorithm for the line balancing problem, Management Science 11 (1964) 308-315] in order to assess the computational complexity of the problem. Such an assessment is not correct since the work of Gutjahr and Nemhauser predates the concept of NP-hardness. This work points at over 50 publications since 1995 with the aforesaid error. (C) 2019 Elsevier Ltd. All rights reserved.
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Alvarez-Miranda, E., Chace, S., & Pereira, J. (2021). Assembly line balancing with parallel workstations. Int. J. Prod. Res., 59(21), 6486–6506.
Abstract: The simple assembly line balancing problem (SALBP) considers work division among different workstations of a serially arranged assembly process to maximise its efficiency under workload (cumulative) and technological (precedence) constraints. In this work, we consider a variant of the SALBP which allows parallel workstations. To study the effect of parallel stations, we propose a new problem (the parallel station assembly line balancing problem or PSALBP) in which the objective is to minimise the number of parallel stations required to obtain the maximum theoretical efficiency of the assembly process. We study the complexity of the problem and identify a polynomially solvable case. This result is then used as a building block for the development of a heuristic solution procedure. Finally, we carry out a computational experiment to identify the characteristics of assembly lines that may benefit from station paralleling and to evaluate the performance of the proposed heuristic.
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Alvarez-Miranda, E., Pereira, J., Torrez-Meruvia H., & Vila, M. (2021). A Hybrid Genetic Algorithm for the Simple Assembly Line Balancing Problem with a Fixed Number of Workstations. Mathematics, 9(17), 2157.
Abstract: The assembly line balancing problem is a classical optimisation problem whose objective is to assign each production task to one of the stations on the assembly line so that the total efficiency of the line is maximized. This study proposes a novel hybrid method to solve the simple version of the problem in which the number of stations is fixed, a problem known as SALBP-2. The hybrid differs from previous approaches by encoding individuals of a genetic algorithm as instances of a modified problem that contains only a subset of the solutions to the original formulation. These individuals are decoded to feasible solutions of the original problem during fitness evaluation in which the resolution of the modified problem is conducted using a dynamic programming based approach that uses new bounds to reduce its state space. Computational experiments show the efficiency of the method as it is able to obtain several new best-known solutions for some of the benchmark instances used in the literature for comparison purposes.
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Alvarez-Miranda, E., Pereira, J., Vargas, C., & Vila, M. (2022). Variable-depth local search heuristic for assembly line balancing problems. Int. J. Prod. Res., 61(9), 3103–3121.
Abstract: Assembly lines are production flow systems wherein activities are organised around a line consisting of various workstations through which the product flows. At each station, the product is assembled through a subset of operations. The assembly line balancing problem (ALBP) consists of allocating operations between stations to maximise the system efficiency. In this study, a variable-depth local search algorithm is proposed for solving simple assembly line balancing problems (SALBPs), which are the most widely studied versions of the ALBP. Although the state-of-the-art techniques for solving the SALBP consist of exact enumeration-based methods or heuristics, this paper proposes a local search-based heuristic using variable-length sequences that allow the solution space to be efficiently explored. The proposed algorithm improves the best solution known for multiple instances reported in the literature, indicating that its efficiency is comparable to those of the state-of-the-art method for solving the SALBP. Moreover, the characteristics of the instances for which the proposed procedure provides a better solution than previously reported construction procedures are investigated.
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Alvarez-Miranda, E., Pereira, J., & Vila, M. (2023). Analysis of the simple assembly line balancing problem complexity. Comput. Oper. Res., 159, 106323.
Abstract: The simple assembly line balancing problem (SALBP) involves the determination of the assignment of elementary assembly operations to the workstations of the assembly line for the manufacture of a final product, with the objective of maximising assembly efficiency. In addition to its practicality, the SALBP can be considered as an extension of the bin packing problem (BPP) to account for the precedence relations between items. These constraints introduce an ordering component to the problem, which increases the complexity of SALBP resolution. However, previous studies indicated that precedence constraints do not play an important role in the capacity of state-of-the-art procedures to solve benchmark instances to optimality. In this study, we analysed the influences of different features of an SALBP instance on the performance of state-of-the-art solution methods for the abovementioned problem. First, we provide an alternative proof of complexity for the SALBP that uses precedence constraints to demonstrate its non-deterministic polynomial time (NP)-complete status, followed by a new set of benchmark instances directed towards an empirical analysis of the different features of SALBP instances. The experimental results revealed that the packing features of the SALBP are a major source of the perceived difficulty for any instance; however, precedence constraints play a role in the performance of these solution procedures. Specifically, the number of precedence constraints plays an important role in the results obtained from state-of-the-art methods. In addition to the analysis, certain issues that were identified in the publicly available implementations of the state-of-the-art method for resolving this problem were addressed in this study.
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Arbelaez, H., Hernandez, R., & Sierra, W. (2022). Lower and upper order of harmonic mappings. J. Math. Anal. Appl., 507(2), 125837.
Abstract: In this paper, we define both the upper and lower order of a sense-preserving harmonic mapping in D. We generalize to the harmonic case some known results about holomorphic functions with positive lower order and we show some consequences of a function having finite upper order. In addition, we improve a related result in the case when there is equality in a known distortion theorem for harmonic mappings with finite upper order. Some examples are provided to illustrate the developed theory. (C) 2021 Elsevier Inc. All rights reserved.
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Asenjo, F. A. (2024). Accelerating self-modulated nonlinear waves in weakly and strongly magnetized relativistic plasmas. J. Plasma Phys., 30(1).
Abstract: It is known that a nonlinear Schrodinger equation describes the self-modulation of a large amplitude circularly polarized wave in relativistic electron-positron plasmas in the weakly and strongly magnetized limits. Here, we show that such an equation can be written as a modified second Painleve equation, producing accelerated propagating wave solutions for those nonlinear plasmas. This solution even allows the plasma wave to reverse its direction of propagation. The acceleration parameter depends on the plasma magnetization. This accelerating solution is different to the usual soliton solution propagating at constant speed.
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Asenjo, F. A., & Hojman, S. A. (2021). Accelerating solutions to diffusion equation. Eur. Phys. J. Plus., 136(6), 677.
Abstract: We report accelerating diffusive solutions to the diffusion equation with a constant diffusion tensor. The maximum values of the diffusion density evolve in an accelerating fashion described by Airy functions. We show the diffusive accelerating behavior for one-dimensional systems, as well as for a general three-dimensional case. We also construct a modulated modified form of the diffusion solution that retains the accelerating features.
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Barrera, J., Moreno, E., & Munoz, G. (2022). Convex envelopes for ray-concave functions. Optim. Let., 16, 2221–2240.
Abstract: Convexification based on convex envelopes is ubiquitous in the non-linear optimization literature. Thanks to considerable efforts of the optimization community for decades, we are able to compute the convex envelopes of a considerable number of functions that appear in practice, and thus obtain tight and tractable approximations to challenging problems. We contribute to this line of work by considering a family of functions that, to the best of our knowledge, has not been considered before in the literature. We call this family ray-concave functions. We show sufficient conditions that allow us to easily compute closed-form expressions for the convex envelope of ray-concave functions over arbitrary polytopes. With these tools, we are able to provide new perspectives to previously known convex envelopes and derive a previously unknown convex envelope for a function that arises in probability contexts.
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Barrera, J., Moreno, E., Munoz, G., & Romero, P. (2022). Exact reliability optimization for series-parallel graphs using convex envelopes. Networks, 80(2), 235–248.
Abstract: Given its wide spectrum of applications, the classical problem of all-terminal network reliability evaluation remains a highly relevant problem in network design. The associated optimization problem-to find a network with the best possible reliability under multiple constraints-presents an even more complex challenge, which has been addressed in the scientific literature but usually under strong assumptions over failures probabilities and/or the network topology. In this work, we propose a novel reliability optimization framework for network design with failures probabilities that are independent but not necessarily identical. We leverage the linear-time evaluation procedure for network reliability in the series-parallel graphs of Satyanarayana and Wood (1985) to formulate the reliability optimization problem as a mixed-integer nonlinear optimization problem. To solve this nonconvex problem, we use classical convex envelopes of bilinear functions, introduce custom cutting planes, and propose a new family of convex envelopes for expressions that appear in the evaluation of network reliability. Furthermore, we exploit the refinements produced by spatial branch-and-bound to locally strengthen our convex relaxations. Our experiments show that, using our framework, one can efficiently obtain optimal solutions in challenging instances of this problem.
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Beya-Marshall, V., Arcos, E., Seguel, O., Galleguillos, M., & Kremer, C. (2022). Optimal irrigation management for avocado (cv. 'Hass') trees by monitoring soil water content and plant water status. Agric. Water Manag., 271, 107794.
Abstract: Irrigation scheduling based on soil water content (Ow) sensors requires that Ow be maintained within a range (management lines) that is optimal for plant growth. The lower limit or “breaking point ” is determined following the soil water content dynamics on the transition of a rapid rate of depletion to a slower, under similar reference evapotranspiration. Although this criterion is practical, its implementation should be validated with plant water status measurement that contemplate weather condition, such as stem water potential “non-stressed ” baseline (Tx as a function of vapor-pressure deficit (VPD) in Ow conditions that do not limit yield). A study was con-ducted on a mature cv. 'Hass' avocado orchard in Central Chile during two seasons. There were 5 irrigation treatments: T1, Control; T2 and T3 with 29% less and 25% more of what was applied in T1, respectively; T4 and T5 same as Control until first and second fruit drop abscission, respectively, and then with 29% less. T1 trees were irrigated using a continuous frequency domain reflectometry (FDR) probe to maintain the root zone be-tween field capacity and the breaking point. There was biweekly monitoring of the Ow prior to irrigation, Tx and VPD. The Tx decline proportional to the intensity and the timing of water restriction; however, no treatment affected the crop load in either season. T2 did not show significant detrimental in fruit size, production and maturation, despite that frequently reached water content levels at the limit of the breaking point, and showed lower levels of stem water potential than Control, being the treatment with the highest water productivity. The results confirm that breaking point is an effective criterion to establish irrigation management. Additionally, when comparing the baseline for our non-stressed trees with a baseline from full irrigation treatments obtained from the literature, 30% water savings were achieved.
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Cardenas, C., Guzman, F., Carmona, M., Munoz, C., Nilo, L., Labra, A., et al. (2020). Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon. Pathogens, 9(8), 600.
Abstract: Viral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies available for either. In this context, antiviral peptides emerge as effective and relatively safe therapeutic molecules. Based on in silico analysis of VP2 protein from IPNV and the RNA-dependent RNA polymerase from ISAV, a set of peptides was designed and were chemically synthesized to block selected key events in their corresponding infectivity processes. The peptides were tested in fish cell lines in vitro, and four were selected for decreasing the viral load: peptide GIM182 for IPNV, and peptides GIM535, GIM538 and GIM539 for ISAV. In vivo tests with the IPNV GIM 182 peptide were carried out using Salmo salar fish, showing a significant decrease of viral load, and proving the safety of the peptide for fish. The results indicate that the use of peptides as antiviral agents in disease control might be a viable alternative to explore in aquaculture.`
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Casassus, S., Carcamo, M., Hales, A., Weber, P., & Dent, B. (2022). The Doppler Flip in HD 100546 as a Disk Eruption: The Elephant in the Room of Kinematic Protoplanet Searches. Astrophys. J. Lett., 933(1), L4.
Abstract: The interpretation of molecular-line data using hydrodynamical simulations of planet-disk interactions fosters new hope for the indirect detection of protoplanets. In a model-independent approach, embedded protoplanets should be found at the roots of abrupt Doppler flips in velocity centroid maps. However, the largest velocity perturbation known for an unwarped disk, in the disk of HD 100546, leads to a conspicuous Doppler flip that coincides with a thick dust ring, in contradiction with an interpretation in terms of a greater than or similar to 1 M-jup body. Here we present new ALMA observations of the (CO)-C-12(2-1) kinematics in HD 100546, with a factor of 2 finer angular resolutions. We find that the disk rotation curve is consistent with a central mass 2.1 < M-*/M-circle dot < 2.3 and that the blueshifted side of the Doppler flip is due to vertical motions, reminiscent of the disk wind proposed previously from blueshifted SO lines. We tentatively propose a qualitative interpretation in terms of a surface disturbance to the Keplerian flow, i.e., a disk eruption, driven by an embedded outflow launched by a similar to 10 M-earth body. Another interpretation involves a disk-mass-loading hot spot at the convergence of an envelope accretion streamer.
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Chuaqui, M., & Hernandez, R. (2007). Univalent harmonic mappings and linearly connected domains. J. Math. Anal. Appl., 332(2), 1189–1194.
Abstract: We investigate the relationship between the univalence of f and of h in the decomposition f = h + (g) over bar of a serise-preserving harmonic mapping defined in the unit disk D subset of C. Among other results, we determine the holomorphic univalent maps It for which there exists c > 0 such that every harmonic mapping of the form f = h + (g) over bar with vertical bar g'vertical bar < c vertical bar h'vertical bar is univalent. The notion of a linearly connected domain appears in our study in a relevant way. (c) 2006 Elsevier Inc. All rights reserved.
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Chuaqui, M., & Hernandez, R. (2013). The order of a linearly invariant family in C-n. J. Math. Anal. Appl., 398(1), 372–379.
Abstract: We study the (trace) order of the linearly invariant family in the ball B-n defined by parallel to SF parallel to <= alpha, where F : B-n -> C-n is locally biholomorphic and SF is the Schwarzian operator. By adapting Pommerenke's approach, we establish a characteristic equation for the extremal mapping that yields an upper bound for the order of the family in terms of alpha and the dimension n. Lower bounds for the order are established in similar terms by means of examples. (C) 2012 Elsevier Inc. All rights reserved.
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Diaz-Rullo, J., Rodriguez-Valdecantos, G., Torres-Rojas, F., Cid, L., Vargas, I. T., Gonzalez, B., et al. (2021). Mining for Perchlorate Resistance Genes in Microorganisms From Sediments of a Hypersaline Pond in Atacama Desert, Chile. Front. Microbiol., 12, 723874.
Abstract: Perchlorate is an oxidative pollutant toxic to most of terrestrial life by promoting denaturation of macromolecules, oxidative stress, and DNA damage. However, several microorganisms, especially hyperhalophiles, are able to tolerate high levels of this compound. Furthermore, relatively high quantities of perchlorate salts were detected on the Martian surface, and due to its strong hygroscopicity and its ability to substantially decrease the freezing point of water, perchlorate is thought to increase the availability of liquid brine water in hyper-arid and cold environments, such as the Martian regolith. Therefore, perchlorate has been proposed as a compound worth studying to better understanding the habitability of the Martian surface. In the present work, to study the molecular mechanisms of perchlorate resistance, a functional metagenomic approach was used, and for that, a small-insert library was constructed with DNA isolated from microorganisms exposed to perchlorate in sediments of a hypersaline pond in the Atacama Desert, Chile (Salar de Maricunga), one of the regions with the highest levels of perchlorate on Earth. The metagenomic library was hosted in Escherichia coli DH10B strain and exposed to sodium perchlorate. This technique allowed the identification of nine perchlorate-resistant clones and their environmental DNA fragments were sequenced. A total of seventeen ORFs were predicted, individually cloned, and nine of them increased perchlorate resistance when expressed in E. coli DH10B cells. These genes encoded hypothetical conserved proteins of unknown functions and proteins similar to other not previously reported to be involved in perchlorate resistance that were related to different cellular processes such as RNA processing, tRNA modification, DNA protection and repair, metabolism, and protein degradation. Furthermore, these genes also conferred resistance to UV-radiation, 4-nitroquinoline-N-oxide (4-NQO) and/or hydrogen peroxide (H2O2), other stress conditions that induce oxidative stress, and damage in proteins and nucleic acids. Therefore, the novel genes identified will help us to better understand the molecular strategies of microorganisms to survive in the presence of perchlorate and may be used in Mars exploration for creating perchlorate-resistance strains interesting for developing Bioregenerative Life Support Systems (BLSS) based on in situ resource utilization (ISRU).
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