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Araya-Letelier, G., Antico, F. C., Carrasco, M., Rojas, P., & Garcia-Herrera, C. M. (2017). Effectiveness of new natural fibers on damage-mechanical performance of mortar. Constr. Build. Mater., 152, 672–682.
Abstract: Addition of fibers to cement-based materials improve tensile and flexural strength, fracture toughness, abrasion resistance, delay cracking, and reduce crack widths. Natural fibers have recently become more popular in the construction materials community. This investigation addresses the characterization of a new animal fiber (pig hair), a massive food-industry waste worldwide, and its use in mortars. Morphological, physical and mechanical properties of pig hair are determined in order to be used as reinforcement in mortars. A sensitivity analysis on the volumes of fiber in mortars is developed. The results from this investigation showed that reinforced mortars significantly improve impact strength, abrasion resistance, plastic shrinkage cracking, age at cracking, and crack widths as fiber volume increases. Other properties such as compressive and flexural strength, density, porosity and modulus of elasticity of reinforced mortars are not significantly affected by the addition of pig hair. (C) 2017 Elsevier Ltd. All rights reserved.
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Araya-Letelier, G., Concha-Riedel, J., Antico, F. C., Valdes, C., & Caceres, G. (2018). Influence of natural fiber dosage and length on adobe mixes damage-mechanical behavior. Constr. Build. Mater., 174, 645–655.
Abstract: This study addresses the use of a natural fiber (pig hair), a massive food-industry waste, as reinforcement in adobe mixes (a specific type of earthen material). The relevance of this work resides in the fact that earthen materials are still widely used worldwide because of their low cost, availability, and low environmental impact. Results show that adobe mixes' mechanical-damage behavior is sensitive to both (i) fiber dosage and (ii) fiber length. Impact strength and flexural toughness are increased, whereas shrinkage distributed crack width is reduced. Average values of compressive and flexural strengths are reduced as fiber dosage and length increase, as a result of porosity generated by fiber clustering. Based on the results of this work a dosage of 0.5% by weight of dry soil using 7 mm fibers is optimal to improve crack control, flexural toughness and impact strength without statistically affecting flexural and compressive strengths. (C) 2018 Elsevier Ltd. All rights reserved.
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Baier, R. V., Raggio, J. I. C., Arancibia, C. T., Bustamante, M., Perez, L., Burda, I., et al. (2021). Structure-function assessment of 3D-printed porous scaffolds by a low-cost/ open source fused filament fabrication printer. Mater. Sci. Eng. C-Mater. Biol. Appl., 123, 111945.
Abstract: Additive manufacturing encompasses a plethora of techniques to manufacture structures from a computational model. Among them, fused filament fabrication (FFF) relies on heating thermoplastics to their fusion point and extruding the material through a nozzle in a controlled pattern. FFF is a suitable technique for tissue engineering, given that allows the fabrication of 3D-scaffolds, which are utilized for tissue regeneration purposes. The objective of this study is to assess a low-cost/open-source 3D printer (In-House), by manufacturing both solid and porous samples with relevant microarchitecture in the physiological range (100?500 ?m pore size), using an equivalent commercial counterpart for comparison. For this, compressive tests in solid and porous scaffolds manufactured in both printers were performed, comparing the results with finite element analysis (FEA) models. Additionally, a microarchitectural analysis was done in samples from both printers, comparing the measurements of both pore size and porosity to their corresponding computer-aided design (CAD) models. Moreover, a preliminary biological assessment was performed using scaffolds from our In-House printer, measuring cell adhesion efficiency. Finally, Fourier transform infrared spectroscopy ? attenuated total reflectance (FTIR?ATR) was performed to evaluate chemical changes in the material (polylactic acid) after fabrication in each printer. The results show that the In-House printer achieved generally better mechanical behavior and resolution capacity than its commercial counterpart, by comparing with their FEA and CAD models, respectively. Moreover, a preliminary biological assessment indicates the feasibility of the In-House printer to be used in tissue engineering applications. The results also show the influence of pore geometry on mechanical properties of 3D-scaffolds and demonstrate that properties such as the apparent elastic modulus (Eapp) can be controlled in 3D-printed scaffolds.
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Collins, C. J., Vivanco, J. F., Sokn, S. A., Williams, B. O., Burgers, T. A., & Ploeg, H. L. (2015). Fracture healing in mice lacking Pten in osteoblasts: a micro-computed tomography image-based analysis of the mechanical properties of the femur. J. Biomech., 48(2), 310–317.
Abstract: In the United States, approximately eight million osseous fractures are reported annually, of which 5-10% fail to create a bony union. Osteoblast-specific deletion of the gene Pten in mice has been found to stimulate bone growth and accelerate fracture healing. Healing rates at four weeks increased in femurs from Pten osteoblast conditional knock-out mice (Pten-CKO) compared to wild-type mice (WT) of the same genetic strain as measured by an increase in mechanical stiffness and failure load in four-point bending tests. Preceding mechanical testing, each femur was imaged using a Skyscan 1172 micro-computed tomography (mu CT) scanner (Skyscan, Kontich, Belgium). The present study used μCT image-based analysis to test the hypothesis that the increased femoral fracture force and stiffness in Pten-CKO were due to greater section properties with the same effective material properties as that of the WT. The second moment of area and section modulus were computed in ImageJ 1.46 (National Institutes of Health) and used to predict the effective flexural modulus and the stress at failure for fourteen pairs of intact and callus WT and twelve pairs of intact and callus Pten-CKO femurs. For callus and intact femurs, the failure stress and tissue mineral density of the Pten-CKO and WT were not different; however, the section properties of the Pten-CKO were more than twice as large 28 days post-fracture. It was therefore concluded, when the gene Pten was conditionally knocked-out in osteoblasts, the resulting increased bending stiffness and force to fracture were due to increased section properties. (C) 2014 Elsevier Ltd. All rights reserved.
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Norambuena-Contreras, J., Gonzalez-Torre, I., Vivanco, J. F., & Gacitua, W. (2016). Nanomechanical properties of polymeric fibres used in geosynthetics. Polym. Test, 54, 67–77.
Abstract: Geosynthetics are composite materials manufactured using different types of polymeric fibres, usually employed as anti-reflective cracking systems in asphalt pavements. Materials that compose geosynthetics can be damaged due to mechanical and thermal effects produced during the installation process under hot mix asphalts. In this paper, different polymeric fibres extracted from geosynthetics have been evaluated using nanoindentation tests. The main objective was to evaluate the effect of installation process (dynamic compaction and thermal damage) on the mechanical behaviour of individual polymeric fibres at nano-scale. To do this, elastic modulus (E) and hardness (H) of three different polymeric fibres commonly used in geosynthetics (polypropylene, polyester and polyvinyl-alcohol), in two testing directions and under two different states have been studied. Main conclusions of this work are that mechanical properties of geosynthetics individual fibres can change after installation, producing changes in the behaviour of geosynthetics at macro-scale with consequences in the pavement functionality, and that these changes are different depending on the material that composed the fibres. (C) 2016 Elsevier Ltd. All rights reserved.
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Slane, J., Vivanco, J., Ebenstein, D., Squire, M., & Ploeg, H. L. (2014). Multiscale characterization of acrylic bone cement modified with functionalized mesoporous silica nanoparticles. J. Mech. Behav. Biomed. Mater., 37, 141–152.
Abstract: Acrylic bone cement is widely used to anchor orthopedic implants to bone and mechanical failure of the cement mantle surrounding an implant can contribute to aseptic loosening. In an effort to enhance the mechanical properties of bone cement, a variety of nanoparticles and fibers can be incorporated into the cement matrix. Mesoporous silica nanoparticles (MSNs) are a class of particles that display high potential for use as reinforcement within bone cement. Therefore, the purpose of this study was to quantify the impact of modifying an acrylic cement with various low-loadings of mesoporous silica. Three types of MSNs (one plain variety and two modified with functional groups) at two loading ratios (0.1 and 0.2 wt/wt) were incorporated into a commercially available bone cement. The mechanical properties were characterized using four-point bending, microindentation and nanoindentation (static, stress relaxation, and creep) while material properties were assessed through dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, FTIR spectroscopy, and scanning electron microscopy. Four-point flexural testing and nanoindentation revealed minimal impact on the properties of the cements, except for several changes in the nano-level static mechanical properties. Conversely, microindentation testing demonstrated that the addition of MSNs significantly increased the microhardness. The stress relaxation and creep properties of the cements measured with nanoindentation displayed no effect resulting from the addition of MSNs. The measured material properties were consistent among all cements. Analysis of scanning electron micrographs images revealed that surface functionalization enhanced particle dispersion within the cement matrix and resulted in fewer particle agglomerates. These results suggest that the loading ratios of mesoporous silica used in this study were not an effective reinforcement material. Future work should be conducted to determine the impact of higher MSN loading ratios and alternative functional groups. (C) 2014 Elsevier Ltd. All rights reserved.
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Slane, J., Vivanco, J., Rose, W., Ploeg, H. L., & Squire, M. (2015). Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles. Mater. Sci. Eng. C-Mater. Biol. Appl., 48, 188–196.
Abstract: Prosthetic joint infection is one of the most serious complications that can lead to failure of a total joint replacement. Recently, the rise of multidrug resistant bacteria has substantially reduced the efficacy of antibiotics that are typically incorporated into acrylic bone cement. Silver nanoparticles (AgNPs) are an attractive alternative to traditional antibiotics resulting from their broad-spectrum antimicrobial activity and low bacterial resistance. The purpose of this study, therefore, was to incorporate metallic silver nanoparticles into acrylic bone cement and quantify the effects on the cement's mechanical, material and antimicrobial properties. AgNPs at three loading ratios (025, 0.5, and 1.0% wt/wt) were incorporated into a commercial bone cement using a probe sonication technique. The resulting cements demonstrated mechanical and material properties that were not substantially different from the standard cement. Testing against Staphylococcus aureus and Staphylococcus epidermidis using Kirby-Bauer and time-kill assays demonstrated no antimicrobial activity against planktonic bacteria. In contrast, cements modified with AgNPs significantly reduced biofilm formation on the surface of the cement. These results indicate that AgNP-loaded cement is of high potential for use in primary arthroplasty where prevention of bacterial surface colonization is vital. (C) 2014 Elsevier B.V. All rights reserved.
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Slane, J. A., Vivanco, J. F., Rose, W. E., Squire, M. W., & Ploeg, H. L. (2014). The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement. Mater. Sci. Eng. C-Mater. Biol. Appl., 42, 168–176.
Abstract: Soluble particulate fillers can be incorporated into antibiotic-loaded acrylic bone cement in an effort to enhance antibiotic elution. Xylitol is a material that shows potential for use as a filler due to its high solubility and potential to inhibit biofilm formation. The objective of this work, therefore, was to investigate the usage of low concentrations of xylitol in a gentamicin-loaded cement. Five different cements were prepared with various xylitol loadings (0, 1, 2.5, 5 or 10 g) per cement unit, and the resulting impact on the mechanical properties, cumulative antibiotic release, biofilm inhibition, and thermal characteristics were quantified. Xylitol significantly increased cement porosity and a sustained increase in gentamicin elution was observed in all samples containing xylitol with a maximum cumulative release of 41.3%. Xylitol had no significant inhibitory effect on biofilm formation. All measured mechanical properties tended to decrease with increasing xylitol concentration; however, these effects were not always significant. Polymerization characteristics were consistent among all groups with no significant differences found. The results from this study indicate that xylitol-modified bone cement may not be appropriate for implant fixation but could be used in instances where sustained, increased antibiotic elution is warranted, such as in cement spacers or beads. (C) 2014 Elsevier B.V. All rights reserved.
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