Abstract: We examine the unexplored effects on art markets of artist death (asset supply constraints), collectors' wealth (background risk) and forgery risk (risk of investment fraud), under short-sale constraints and risk aversion. Speculative bubbles emerge and have the form of an option strangle (a put option and a call option), in which strike prices are affected by art supply constraints and the association of the artworks' emotional value with both collectors' wealth and forgery, while the options' underlying asset is the stochastic heterogeneous beliefs of agents. We show that speculative bubbles increase with four elements: art supply constraints; a more negative correlation between collectors' wealth and the artworks' emotional value; a more positive relationship between forgery and the artworks' emotional value; and more heterogeneous beliefs. These four sources of speculation increase the expected turnover rate; however, they also augment the variance of speculative bubbles, which generates price discounts (i.e. risk premiums) for holding artworks. Consequently, the net impact of speculation is not necessarily increased art prices. This study not only contributes to the art market literature, but also to studies about speculative bubbles in other financial markets under heterogeneous beliefs, short-sale constraints and risk-averse investors, since we additionally consider the simultaneous effect of asset supply constraints, investors' background risk and the risk of investment fraud.

Abstract: This study assesses the effect of the stiffness on the seismic performance of residential shear wall buildings designed according to current Chilean regulations, including DS60 and DS61. Specifically, the paper focuses on the effect of stiffness on the building overstrength, displacement ductility, fragility for Life Safety (LS) and collapse limit states, as well as the probability of achieving these two limits states in 50 years. The seismic performance is assessed for a group of four 20 -story residential shear wall buildings archetypes located in Santiago. Walls were modeled using the multiple vertical line element model (MVLEM) with inelastic hysteretic materials for the vertical elements, and a linear -elastic shear behavior. Pushover analyses were considered to estimate the buildings overstrength and displacement ductility, while incremental dynamic analyses were per- formed to estimate fragility curves. A probabilistic seismic hazard analysis, which considered the seismicity of Chile central zone, was performed to estimate the probability of achieving the two limits states in 50 years. The results show that an increase in the stiffness reduces the chance of exceeding the LS and collapse limit states for the same intensity level. Additionally, the probabilistic seismic hazard analysis shows that, when the stiffness increases, the probability of reaching the LS limit state in 50 years also decreases. Counterintuitively, the probability of collapse in 50 years increases as the stiffness increases, due to the considered seismic hazard and the design requirements. Since society is moving towards resilient structural designs that minimize damage, disruption and economic losses, it is concluded that the performance of reinforced concrete shear wall buildings is improved by increasing the stiffness.

Abstract: Viral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies available for either. In this context, antiviral peptides emerge as effective and relatively safe therapeutic molecules. Based on in silico analysis of VP2 protein from IPNV and the RNA-dependent RNA polymerase from ISAV, a set of peptides was designed and were chemically synthesized to block selected key events in their corresponding infectivity processes. The peptides were tested in fish cell lines in vitro, and four were selected for decreasing the viral load: peptide GIM182 for IPNV, and peptides GIM535, GIM538 and GIM539 for ISAV. In vivo tests with the IPNV GIM 182 peptide were carried out using Salmo salar fish, showing a significant decrease of viral load, and proving the safety of the peptide for fish. The results indicate that the use of peptides as antiviral agents in disease control might be a viable alternative to explore in aquaculture.`

Abstract: Objectives: We examined if the guidelines for gestational weight gain (GWG) proposed by the Institute of Medicine (IOM) are the most suitable for Chilean women. Study design: Secondary analysis of records of single full-term births at the Dr. Sotero del Rio Hospital, Santiago, Chile, during 2003-2012 (n = 62,579). Methods: From clinical records, we obtained data regarding maternal age, height, prepregnancy and at delivery weights, pathologies during pregnancy such as gestational diabetes (GDM) and pre-eclampsia, gestational age at delivery, and number of infants born small for gestational age (SGA) and large for gestational age (LGA). We formulated a mathematical model (MM) to determine the GWG range that maximizes the likelihood of a healthy pregnancy (HP) if the recommendation is followed. We defined an HP as one where the mother has no complications such as pre-eclampsia, GDM, SGA, or LGA. Results: Forty-six percent of women had prepregnancy overweight or obesity. The prevalence of GDM, pre-eclampsia, SGA, and LGA were 3%, 1.2%, 9%, and 12%, respectively. An HP was present in 76% of pregnancies, 79% in the underweight group, 79% in normal weight group, 74% in the overweight group, and 67% in obese women. The GWG recommendations given by the MM (14-20 kg for underweight, 6-20 kg for normal weight, 9 -11 kg for overweight, and 6-7 kg for obese) led to higher probabilities of achieving an HP than the ones obtained with the IOM recommendations. Conclusion: The adoption of GWG recommendations based on characteristics of the Chilean population might lead to better short- and long-term health results for pregnant women. (C) 2018 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Abstract: The research community's attention has been attracted to the reliability of networks exposed to large-scale disasters and this has become a critical concern in network studies during the last decade. Earthquakes are high on the list of those showing the most significant impacts on communication networks, and simultaneously, they are the least predictable events. This study uses the Probabilistic Seismic Hazard Analysis method to estimate the network element state after an earthquake. The approach considers a seismic source model and ground prediction equations to assess the intensity measure for each element according to its location. In the simulation, nodes fail according to the building's fragility curves. Similarly, links fail according to a failure rate depending on the intensity measure and the cable's characteristics. We use the source-terminal, and the diameter constrained reliability metrics. The approach goes beyond the graph representation of the network and incorporates the terrain characteristics and the component's robustness into the network performance analysis at an affordable computational cost. We study the method on a network in a seismic region with almost 9000 km of optical fiber. We observed that for source-terminal that are less than 500 km apart the improvements are marginals while for those that are more than 1000 km apart, reliability improves near a 30% in the enhanced designs. We also showed that these results depend heavily on the robustness/fragility of the infrastructure, showing that performance measures based only the network topology are not enough to evaluate new designs.

Abstract: Context: Voice break, as a landmark of advanced male puberty in genome-wide association studies (GWAS), has revealed that pubertal timing is a highly polygenic trait. Although voice break is easily recorded in large cohorts, it holds quite low precision as a marker of puberty. In contrast, gonadarche and pubarche are early and clinically well-defined measures of puberty onset. Objective: To determine whether a polygenic risk score (PRS) of alleles that confer risk for voice break associates with age at gonadarche (AAG) and age at pubarche (AAP) in Chilean boys. Experimental Design: Longitudinal study. Subjects and Methods: 401 boys from the Growth and Obesity Chilean Cohort Study (n = 1194; 49.2% boys). Main Outcome Measures: Biannual clinical pubertal staging including orchidometry. AAG and AAP were estimated by censoring methods. Genotyping was performed using the Multi-Ethnic Global Array (Illumina). Using GWAS summary statistics from the UK-Biobank, 29 significant and independent single nucleotide polymorphisms associated with age at voice break were extracted. Individual PRS were computed as the sum of risk alleles weighted by the effect size. Results: The PRS was associated with AAG (beta=0.01, P = 0.04) and AAP (beta=0.185, P = 0.0004). In addition, boys within the 20% highest PRS experienced gonadarche and pubarche 0.55 and 0.67 years later than those in the lowest 20%, respectively (P = 0.013 and P = 0.007). Conclusions: Genetic variants identified in large GWAS on age at VB significantly associate with age at testicular growth and pubic hair development, suggesting that these events share a genetic architecture across ethnically distinct populations.

Abstract: Centralized energy auctions for long-term contracts are commonly-used mechanisms to ensure supply adequacy, to promote competition, and to protect retail customers from price spikes in Latin America. In Chile, the law mandates that all distribution companies must hold long-term contracts – which are awarded on a competitive centralized auction – to cover 100% of the projected demand from three to fifteen years into the future. These contracts can be indexed to a series of financial parameters, including fossil fuel prices at reference locations. Drawing from portfolio theory, we use a simple example to illustrate the difficulties of selecting, through the current clearing mechanism that focuses on average costs and individual characteristics of the offers, a portfolio of long-term energy contracts that could simultaneously minimize the expected future cost of energy and limit the risk exposure of retail customers. In particular, we show that if the objective of the regulator is to limit the risk to regulated consumers, it could be optimal to include contracts that would not be selected based on individual characteristics of the offers and a least-cost auction objective, but that could significantly reduce the price variance of the overall portfolio due to diversification effects between indexing parameters.

Abstract: Water is essential for the survival of all living beings and plays a significant role in the growth of any country ' s economy. At present, water depletion and pollution are a serious challenge due to anthropogenic, geogenic and climate change activities worldwide, including in Chile. The Antofagasta region is located in northern Chile and is the heart of its mining industry, playing a significant role in the country ' s economy. The Antofagasta region ' s main challenge is water shortage and contamination. Due to it, the region ' s local population is facing major difficulties in obtaining the necessary water for domestic, industrial, irrigation, and other uses. Therefore, a water resources management plan is essential for the region to maintain a sustainable environment. Considering the above points, significant parameters, such as slope, aspect, elevation, hillshade, drainage, drainage density and river basin-maps of the Antofagasta region prepared using the digital elevation model (DEM) data in geographic information system (GIS) environment. Besides, a pollution risk level assessment of the study area ' s cities/villages done using GIS application. The important created maps and the identification of pollution risk of cities/villages of the present study could provide significant information to policymakers and help them make a suitable water management plan for the area.