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Abarzua, N., Pomareda, R., & Vega, O. (2018). Feet in orthogonal-Buekenhout-Metz unitals. Adv. Geom., 18(2), 229–236.
Abstract: Given an orthogonal-Buekenhout-Metz unital U-alpha,U-beta, embedded in PG(2, q(2)), and a point P is not an element of U-alpha,U-beta, we study the set tau(p)(U-alpha,U-beta) of feet of P in U-alpha,U-beta. We characterize geometrically each of these sets as either q + 1 collinear points or as q + 1 points partitioned into two arcs. Other results about the geometry of these sets are also given.
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Acuna, J. A., Cantarino, D., Martinez, R., & Zayas-Castro, J. L. (2024). A two-stage stochastic game model for elective surgical capacity planning and investment. Socio-Econ. Plan. Sci., 91, 101786.
Abstract: Waiting for elective procedures has become a major health concern in both rich and poor countries. The inadequate balance between the demand for and the supply of health services negatively affects the quality of life, mortality, and government appraisal. This study presents the first mathematical framework shedding light on how much, when, and where to invest in health capacity to end waiting lists for elective surgeries. We model the healthcare system as a two-stage stochastic capacity expansion problem where government investment decisions are represented as a non-symmetric Nash bargaining solution. In particular, the model assesses the capacity requirements, optimal allocation, and corresponding financial investment per hospital, region, specialty, and year. We use the proposed approach to target Chile's elective surgical waiting lists (2021- 2031), considering patients' priorities, 10 regional health services, 24 hospitals, and 10 surgical specialties. We generate uncertain future demand scenarios using historical data (2012-2021) and 100 autoregressive integrated moving average prediction models. The results indicate that USD 3,331.677 million is necessary to end the waiting lists by 2031 and that the Nash approach provides a fair resource distribution with a 6% efficiency loss. Additionally, a smaller budget (USD 2,000 million) was identified as necessary to end the waiting lists in a longer planning horizon. Further analysis revealed the impact of investment in patient transfer and a decline in investment yield.
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Acuna, M., Eaton, L., & Cifuentes, L. (2004). Genetic variants of the paraoxonases (PON1 and PON2) in the Chilean population. Hum. Biol., 76(2), 299–305.
Abstract: We estimated the frequencies of PON1 and PON2 variants (linked genes) in two hospital samples taken from the northern (San Jose Hospital, SJH) and eastern (Clinica Las Condes, CLC) parts of Santiago, Chile, using the polymerase chain reaction followed by restriction endonuclease digestion. The two hospital samples have different degrees of Amerindian admixture (SJH, 34.5%; CLC, 15.9%), which is reflected in the observed frequencies of the PON1*B allele (SJH, 43.1%; CLC, 33.7%) and the PON2*S allele (SJH, 86.3%; CLC, 77.6%); both allele frequencies are significantly different between samples. The frequencies of the combined PON1-PON2 genotypes *A/*B-*C/*C, *A/*B-*S/*S, and *B/*B-*S/*S and of the haplotypes PON*A,C and PON*B,S were significantly different between the SJH and CLC groups. None of the genotype frequencies deviated significantly from those predicted by the Hardy-Weinberg equation. No linkage disequilibrium was found between the PON1 alleles and any of the PON2 alleles in either group (all p > 0.05). In our samples 38.52% (SJH) and 26.25% (CLC) of chromosomes must have the haplotype PON*B,S, presumed to be related to the risk of coronary artery disease. Twenty-four of 193 (12.4%) SJH individuals and 7 of 122 (5.7%) CLC individuals were homozygotes for this haplotype. Finally, our data indicate ethnic-group-dependent genetic differences in the vulnerability to toxic organophosphorus.
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Acuna, M., Eaton, L., Ramirez, N. R., Cifuentes, L., & Llop, E. (2003). Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians. Am. J. Phys. Anthropol., 121(1), 81–85.
Abstract: We estimated the frequencies of serum butyrylcholinesterase (BChE) alleles in three tribes of Mapuche Indians from southern Chile, using enzymatic methods, and we estimated the frequency of allele BCHE*K in one tribe using primer reduced restriction analysis (PCR-PIRA). The three tribes have different degrees of European admixture, which is reflected in the observed frequencies of the atypical allele BCHE*A: 1.11% in Huilliches, 0.89% in Cuncos, and 0% in Pehuenches. This result is evidence in favor of the hypothesis that BCHE*A is absent in native Amerindians. The frequencies of BCHE*F were higher than in most reported studies (3.89%, 5.78%, and 4.41%, respectively). These results are probably due to an overestimation of the frequency of allele BCHE*F, since none of the 20 BCHE UF individuals (by the enzymatic test) individuals analyzed showed either of the two DNA base substitutions associated with this allele. Although enzymatic methods rarely detect the presence of allele BCHE*K, PCR-PIRA found the allele in an appreciable frequency (5.76%), although lower than that found in other ethnic groups. Since observed frequencies of unusual alleles correspond to estimated percentages of European admixture, it is likely that none of these unusual alleles were present in Mapuche Indians before the arrival of Europeans. (C) 2003 Wiley-Liss, Inc.
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Addison, B. C., Wright, D. J., Nicholson, B. A., Cale, B., Mocnik, T., Huber, D., et al. (2021). TOI-257b (HD 19916b): a warm sub-saturn orbiting an evolved F-type star. Mon. Not. Roy. Astron. Soc., 502(3), 3704–3722.
Abstract: We report the discovery of a warm sub-Saturn, TOI-257b (HD 19916b), based on data from NASA's Transiting Exoplanet Survey Satellite (TESS). The transit signal was detected by TESS and confirmed to be of planetary origin based on radial velocity observations. An analysis of the TESS photometry, the MINERVA-Australis, FEROS, and HARPS radial velocities, and the asteroseismic data of the stellar oscillations reveals that TOI-257b has a mass of M-P = 0.138 +/- 0.023M(J) (43.9 +/- 7.3 M-circle plus), a radius of R-P = 0.639 +/- 0.013 R-J (7.16 +/- 0.15 R-circle plus), bulk density of 0.65(-0.11)(+0.12) (cgs), and period 18.38818(-0.00084)(+0.00085) days. TOI-257b orbits a bright (V = 7.612 mag) somewhat evolved late F-type star with M-* = 1.390 +/- 0.046(Msun), R-* = 1.888 +/- 0.033 R-sun, T-eff = 6075 +/- 90 K, and vsin i = 11.3 +/- 0.5 kms(-1). Additionally, we find hints for a second non-transiting sub-Saturn mass planet on a similar to 71 day orbit using the radial velocity data. This system joins the ranks of a small number of exoplanet host stars (similar to 100) that have been characterized with asteroseismology. Warm sub-Saturns are rare in the known sample of exoplanets, and thus the discovery of TOI-257b is important in the context of future work studying the formation and migration history of similar planetary systems.
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Affolter, C., Kedzierska, J., Vielma, T., Weisse, B., & Aiyangar, A. (2020). Estimating lumbar passive stiffness behaviour from subject-specific finite element models and in vivo 6DOF kinematics. J. Biomech., 102, 11 pp.
Abstract: Passive rotational stiffness of the osseo-ligamentous spine is an important input parameter for estimating in-vivo spinal loading using musculoskeletal models. These data are typically acquired from cadaveric testing. Increasingly, they are also estimated from subject-specific imaging-based finite element (FE) models, which are typically built from CT/MR data obtained in supine position and employ pure rotation kinematics. We explored the sensitivity of FE-based lumbar passive rotational stiffness to two aspects of functional in-vivo kinematics: (a) passive strain changes from supine to upright standing position, and (b) in-vivo coupled translation-rotation kinematics. We developed subject-specific FE models of four subjects' L4L5 segments from supine CT images. Sagittally symmetric flexion was simulated in two ways: (i) pure flexion up to 12 degrees under a 500 N follower load directly from the supine pose. (ii) First, a displacement-based approach was implemented to attain the upright pose, as measured using Dynamic Stereo X-ray (DSX) imaging. We then simulated in-vivo flexion using DSX imaging-derived kinematics. Datasets from weight-bearing motion with three different external weights [(4.5 kg), (9.1 kg), (13.6 kg)] were used. Accounting for supine-upright motion generated compressive pre-loads approximate to 468 N (+/- 188 N) and a “pre-torque” approximate to 2.5 Nm (+/- 2.2 Nm), corresponding to 25% of the reaction moment at 10 degrees flexion (case (i)). Rotational stiffness estimates from DSX-based coupled translation-rotation kinematics were substantially higher compared to pure flexion. Reaction Moments were almost 90% and 60% higher at 5 degrees and 10 degrees of L4L5 flexion, respectively. Within-subject differences in rotational stiffness based on external weight were small, although between-subject variations were large. (C) 2020 Elsevier Ltd. All rights reserved.
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Agostini, C. A., Guzman, A. M., Nasirov, S., & Silva, C. (2019). A surplus based framework for cross-border electricity trade in South America. Energy Policy, 128, 673–684.
Abstract: The South American region has experienced a steady increase in its demand for electricity and faces several challenges in the development of the electricity sector. Among them, high fluctuations in hydro generation, high and volatile prices of fossil fuels, and environmental and social impacts associated to energy activities. Strengthening cooperation for cross-border electricity trade is considered a sustainable alternative for addressing these challenges. For the expansion of electricity trade among countries within the region, both infrastructure and a regulation that defines the conditions of the electric power exchanges between countries are required. A good regulatory framework would allow all market players to have access to the commercialization of energy with other countries in the region, guarantee that the treatment of exchanges is non-discriminatory, and maintain the efficiency, cost effectiveness and security characteristics operation of all electricity systems. In this context, this paper proposes a framework with the basic setting conditions for the import and export of energy from the “surplus” available for exchange. The empirical analysis of the regulatory proposal, based on simulations, shows that the exchange of energy from Chile with its neighboring countries is feasible in a clear and transparent manner, reducing the marginal costs of energy and the total cost of operation, keeping the average cost of generation relatively constant.
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Agostini, C. A., Silva, C., & Nasirov, S. (2017). Failure of Energy Mega-Projects in Chile: A Critical Review from Sustainability Perspectives. Sustainability, 9(6), 17 pp.
Abstract: A number of successive energy crises over the last decade due to the lack of a balanced investment planning in the energy sector in Chile has led to a strong dependence on external sources and also doubled energy prices in the country, thus posing a significant challenge to the local economy. With the purpose of reaching long-term goals while simultaneously addressing short-term urgencies, Chile seeks to build a consistent and integrated energy policy in order to attract investment in the sector. Despite an overall attractive investment climate and encouraging market conditions in the country, the energy sector has been adversely affected, in particular, by the communities' opposition to mega-projects based on their expected environmental and social impacts. The study highlights recent experiences of energy generation mega-projects in terms of addressing aspects of sustainability. Based on these experiences, it discusses underdeveloped role of environmental evaluations and the main regulatory challenges ahead, recommending then public policies to effectively address these challenges.
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Aguilera, V. M., Vargas, C. A., Lardies, M. A., & Poupin, M. J. (2016). Adaptive variability to low-pH river discharges in Acartia tonsa and stress responses to high PCO2 conditions. Mar. Ecol.-Evol. Persp., 37(1), 215–226.
Abstract: Environmental transitions leading to spatial physical-chemical gradients are of ecological and evolutionary interest because they are able to induce variations in phenotypic plasticity. Thus, the adaptive variability to low-pH river discharges may drive divergent stress responses [ingestion rates (IR) and expression of stress-related genes such as Heat shock protein 70 (Hsp70) and Ferritin] in the neritic copepod Acartia tonsa facing changes in the marine chemistry associated to ocean acidification (OA). These responses were tested in copepod populations inhabiting two environments with contrasting carbonate system parameters (an estuarine versus coastal area) in the Southern Pacific Ocean, and assessing an insitu and 96-h experimental incubation under conditions of high pressure of CO2 (PCO2 1200ppm). Adaptive variability was a determining factor in driving variability of copepods' responses. Thus, the food-rich but colder and corrosive estuary induced a traits trade-off expressed as depressed IR under insitu conditions. However, this experience allowed these copepods to tolerate further exposure to high PCO2 levels better, as their IRs were on average 43% higher thanthose of the coastal individuals. Indeed, expression of both the Hsp70 and Ferritin genes in coastal copepods was significantly higher after acclimation to high PCO2 conditions. Along with other recent evidence, our findings confirm that adaptation to local fluctuations in seawater pH seems to play a significant role in the response of planktonic populations to OA-associated conditions. Facing the environmental threat represented by the inter-play between multiple drivers of climate change, this biological feature should be examined in detail asa potential tool for risk mitigation policies in coastal management arrangements.
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Aiyangar, A. K., Vivanco, J., Au, A. G., Anderson, P. A., Smith, E. L., & Ploeg, H. L. (2014). Dependence of Anisotropy of Human Lumbar Vertebral Trabecular Bone on Quantitative Computed Tomography-Based Apparent Density. J. Biomech. Eng.-Trans. ASME, 136(9), 10 pp.
Abstract: Most studies investigating human lumbar vertebral trabecular bone (HVTB) mechanical property-density relationships have presented results for the superior-inferior (SI), or “ on-axis” direction. Equivalent, directly measured data from mechanical testing in the transverse (TR) direction are sparse and quantitative computed tomography (QCT) density-dependent variations in the anisotropy ratio of HVTB have not been adequately studied. The current study aimed to investigate the dependence of HVTB mechanical anisotropy ratio on QCT density by quantifying the empirical relationships between QCT-based apparent density of HVTB and its apparent compressive mechanical propertieselastic modulus (E-app), yield strength (sigma(y)), and yield strain (epsilon(y))-in the SI and TR directions for future clinical QCT-based continuum finite element modeling of HVTB. A total of 51 cylindrical cores (33 axial and 18 transverse) were extracted from four L1 human lumbar cadaveric vertebrae. Intact vertebrae were scanned in a clinical resolution computed tomography (CT) scanner prior to specimen extraction to obtain QCT density, rho(CT). Additionally, physically measured apparent density, computed as ash weight over wet, bulk volume, rho(app), showed significant correlation with rho(CT) [rho(CT) = 1.0568 x rho(app), r = 0.86]. Specimens were compression tested at room temperature using the Zetos bone loading and bioreactor system. Apparent elastic modulus (E-app) and yield strength (sigma(y)) were linearly related to the rho(CT) in the axial direction [E-SI = 1493.8 x (rho(CT)), r = 0.77, p < 0.01; sigma(Y,SI) = 6.9 x (rho(CT)) = 0.13, r = 0.76, p < 0.01] while a power-law relation provided the best fit in the transverse direction [E-TR 3349.1 x (rho(CT))(1.94), r = 0.89, p < 0.01; sigma(Y,TR) 18.81 x (rho(CT)) 1.83, r = 0.83, p < 0.01]. No significant correlation was found between epsilon(y) and rho(CT) in either direction. E-app and sigma(y) in the axial direction were larger compared to the transverse direction by a factor of 3.2 and 2.3, respectively, on average. Furthermore, the degree of anisotropy decreased with increasing density. Comparatively, epsilon(y) exhibited only a mild, but statistically significant anisotropy: transverse strains were larger than those in the axial direction by 30%, on average. Ability to map apparent mechanical properties in the transverse direction, in addition to the axial direction, from CT-based densitometric measures allows incorporation of transverse properties in finite element models based on clinical CT data, partially offsetting the inability of continuum models to accurately represent trabecular architectural variations.
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Akhmediev, N., Kibler, B., Baronio, F., Belic, M., Zhong, W. P., Zhang, Y. Q., et al. (2016). Roadmap on optical rogue waves and extreme events. J. Opt., 18(6), 37 pp.
Abstract: The pioneering paper 'Optical rogue waves' by Solli et al (2007 Nature 450 1054) started the new subfield in optics. This work launched a great deal of activity on this novel subject. As a result, the initial concept has expanded and has been enriched by new ideas. Various approaches have been suggested since then. A fresh look at the older results and new discoveries has been undertaken, stimulated by the concept of 'optical rogue waves'. Presently, there may not by a unique view on how this new scientific term should be used and developed. There is nothing surprising when the opinion of the experts diverge in any new field of research. After all, rogue waves may appear for a multiplicity of reasons and not necessarily only in optical fibers and not only in the process of supercontinuum generation. We know by now that rogue waves may be generated by lasers, appear in wide aperture cavities, in plasmas and in a variety of other optical systems. Theorists, in turn, have suggested many other situations when rogue waves may be observed. The strict definition of a rogue wave is still an open question. For example, it has been suggested that it is defined as 'an optical pulse whose amplitude or intensity is much higher than that of the surrounding pulses'. This definition (as suggested by a peer reviewer) is clear at the intuitive level and can be easily extended to the case of spatial beams although additional clarifications are still needed. An extended definition has been presented earlier by N Akhmediev and E Pelinovsky (2010 Eur. Phys. J. Spec. Top. 185 1-4). Discussions along these lines are always useful and all new approaches stimulate research and encourage discoveries of new phenomena. Despite the potentially existing disagreements, the scientific terms 'optical rogue waves' and 'extreme events' do exist. Therefore coordination of our efforts in either unifying the concept or in introducing alternative definitions must be continued. From this point of view, a number of the scientists who work in this area of research have come together to present their research in a single review article that will greatly benefit all interested parties of this research direction. Whether the authors of this 'roadmap' have similar views or different from the original concept, the potential reader of the review will enrich their knowledge by encountering most of the existing views on the subject. Previously, a special issue on optical rogue waves (2013 J. Opt. 15 060201) was successful in achieving this goal but over two years have passed and more material has been published in this quickly emerging subject. Thus, it is time for a roadmap that may stimulate and encourage further research.
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Akian, M., Gaubert, S., & Hochart, A. (2020). A Game Theory Approach To The Existence And Uniqueness Of Nonlinear Perron-Frobenius Eigenvectors. Discret. Contin. Dyn. Syst., 40(1), 207–231.
Abstract: We establish a generalized Perron-Frobenius theorem, based on a combinatorial criterion which entails the existence of an eigenvector for any nonlinear order-preserving and positively homogeneous map f acting on the open orthant R->0(n). This criterion involves dominions, i.e., sets of states that can be made invariant by one player in a two-person game that only depends on the behavior of f “at infinity”. In this way, we characterize the situation in which for all alpha, beta > 0, the “slice space” S-alpha(beta) :={x is an element of R->0(n) vertical bar alpha x <= f(x) <= beta x} is bounded in Hilbert's projective metric, or, equivalently, for all uniform perturbations g of f, all the orbits of g are bounded in Hilbert's projective metric. This solves a problem raised by Gaubert and Gunawardena (Trans. AMS, 2004). We also show that the uniqueness of an eigenvector is characterized by a dominion condition, involving a different game depending now on the local behavior of f near an eigenvector. We show that the dominion conditions can be verified by directed hypergraph methods. We finally illustrate these results by considering specific classes of nonlinear maps, including Shapley operators, generalized means and nonnegative tensors.
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Alcaino, P., Santa-Maria, H., Magna-Verdugo, C., & Lopez, L. (2020). Experimental fast-assessment of post-fire residual strength of reinforced concrete frame buildings based on non-destructive tests. Constr. Build. Mater., 234, 10 pp.
Abstract: Assessment of the residual strength of reinforced concrete buildings subjected to fire is a problem that requires fast and sufficiently reliable resolution, necessary for the action of firefighters, forensic fire investigation, and structural assessment of post-fire condition of the building to take place. In all cases safety and integrity of firefighters and researchers can be at risk, and it is necessary to have rapidly and sufficiently reliable information in order to choose whether to enter freely, to enter with caution, or simply do not enter to the burned structure. This required prompt assessment gives no time or background to develop mathematical models of the structure and damage propagation. This work presents an experimental methodology for a fast assessment of post-fire residual strength of reinforced concrete frame buildings based on the high correlation between the loss of strength and non-destructive test results of frame concrete elements subjected to fire action. (C) 2019 Elsevier Ltd. All rights reserved.
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Aledo, J. A., Goles, E., Montalva-Medel, M., Montealegre, P., & Valverde, J. C. (2023). Symmetrizable Boolean networks. Inf. Sci., 626, 787–804.
Abstract: In this work, we provide a procedure that allows us to transform certain kinds of deterministic Boolean networks on minterm or maxterm functions into symmetric ones, so inferring that such symmetrizable networks can present only periodic points of periods 1 or 2. In particular, we deal with generalized parallel (or synchronous) dynamical systems (GPDS) over undirected graphs, i. e., discrete parallel dynamical systems over undirected graphs where some of the self-loops may not appear. We also study the class of anti-symmetric GPDS (which are non-symmetrizable), proving that their periodic orbits have period 4. In addition, we introduce a class of non-symmetrizable systems which admit periodic orbits with arbitrary large periods.
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Alejo, L., Atkinson, J., Guzman-Fierro, V., & Roeckel, M. (2018). Effluent composition prediction of a two-stage anaerobic digestion process: machine learning and stoichiometry techniques. Environ. Sci. Pollut. Res., 25(21), 21149–21163.
Abstract: Computational self-adapting methods (Support Vector Machines, SVM) are compared with an analytical method in effluent composition prediction of a two-stage anaerobic digestion (AD) process. Experimental data for the AD of poultry manure were used. The analytical method considers the protein as the only source of ammonia production in AD after degradation. Total ammonia nitrogen (TAN), total solids (TS), chemical oxygen demand (COD), and total volatile solids (TVS) were measured in the influent and effluent of the process. The TAN concentration in the effluent was predicted, this being the most inhibiting and polluting compound in AD. Despite the limited data available, the SVM-based model outperformed the analytical method for the TAN prediction, achieving a relative average error of 15.2% against 43% for the analytical method. Moreover, SVM showed higher prediction accuracy in comparison with Artificial Neural Networks. This result reveals the future promise of SVM for prediction in non-linear and dynamic AD processes.
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Alejo, L., Atkinson, J., & Lackner, S. (2020). Looking deeper – exploring hidden patterns in reactor data of N-removal systems through clustering analysis. Water Sci. Technol., 81(8), 1569–1577.
Abstract: In this work, clustering analysis of two partial nitritation-anammox (PN-A) moving bed biofilm reactors (MBBR) containing different types of carrier material was explored for the identification of patterns and operational conditions that may benefit process performance. The systems ran for two years under fluctuations of temperature and organic matter. Ex situ batch activity tests were performed every other week during the operation of these reactors. These datasets and the parameters, which were monitored online and in the laboratory, were combined and analyzed applying clustering analysis to identify non-obvious information regarding the performance of the systems. The initial results were consistent with the literature and from an operational perspective, which allowed the parameters to be explored further. The new information revealed that the oxidation reduction potential (ORP) and the anaerobic ammonium oxidizing bacteria (AnAOB) activity correlated well. ORP also dropped when the reactors were exposed to real wastewater (presence of organic matter). Moreover, operating conditions during nitrite accumulation were identified through clustering, and also revealed inhibition of anammox bacteria already at low nitrite concentrations.
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Alfaro, J., Rubio, C., & San Martin, M. (2023). Cosmological Fluctuations in Delta Gravity. Universe, 9(7), 315.
Abstract: About 70% of the Universe is Dark Energy, but the physics community still does not know what it is. Delta gravity (DG) is an alternative theory of gravitation that could solve this cosmological problem. Previously, we studied the Universe's accelerated expansion, where DG was able to explain the SNe-Ia data successfully. In this work, we computed the cosmological fluctuations in DG that give rise to the CMB through a hydrodynamic approximation. We calculated the gauge transformations for the metric and the perfect fluid to present the equations of the evolution of cosmological fluctuations. This provided the necessary equations to solve the scalar TT power spectrum in a semi-analytical way. These equations are useful for comparing the DG theory with astronomical observations and thus being able to constrain the DG cosmology.
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Allende, C., Sohn, E., & Little, C. (2015). Treelink: data integration, clustering and visualization of phylogenetic trees. BMC Bioinformatics, 16, 6 pp.
Abstract: Background: Phylogenetic trees are central to a wide range of biological studies. In many of these studies, tree nodes need to be associated with a variety of attributes. For example, in studies concerned with viral relationships, tree nodes are associated with epidemiological information, such as location, age and subtype. Gene trees used in comparative genomics are usually linked with taxonomic information, such as functional annotations and events. A wide variety of tree visualization and annotation tools have been developed in the past, however none of them are intended for an integrative and comparative analysis. Results: Treelink is a platform-independent software for linking datasets and sequence files to phylogenetic trees. The application allows an automated integration of datasets to trees for operations such as classifying a tree based on a field or showing the distribution of selected data attributes in branches and leafs. Genomic and proteonomic sequences can also be linked to the tree and extracted from internal and external nodes. A novel clustering algorithm to simplify trees and display the most divergent clades was also developed, where validation can be achieved using the data integration and classification function. Integrated geographical information allows ancestral character reconstruction for phylogeographic plotting based on parsimony and likelihood algorithms. Conclusion: Our software can successfully integrate phylogenetic trees with different data sources, and perform operations to differentiate and visualize those differences within a tree. File support includes the most popular formats such as newick and csv. Exporting visualizations as images, cluster outputs and genomic sequences is supported. Treelink is available as a web and desktop application at http://www. treelinkapp. com.
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Allende, H., Bravo, D., & Canessa, E. (2010). Robust design in multivariate systems using genetic algorithms. Qual. Quant., 44(2), 315–332.
Abstract: This paper presents a methodology based oil genetic algorithms, which finds feasible and reasonably adequate Solutions to problems of robust design in multivariate systems. We use a genetic algorithm to determine the appropriate control factor levels for simultaneously optimizing all of the responses of the system, considering the noise factors which affect it. The algorithm is guided by a desirability function which works with only one fitness function although the system May have many responses. We validated the methodology using data obtained from a real system and also from a process simulator, considering univariate and multivariate systems. In all cases, the methodology delivered feasible solutions, which accomplished the goals of robust design: obtain responses very close to the target values of each of them, and with minimum variability. Regarding the adjustment of the mean of each response to the target value, the algorithm performed very well. However, only in some of the multivariate cases, the algorithm was able to significantly reduce the variability of the responses.
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Allende, H., Elias, C., & Torres, S. (2004). Estimation of the option prime: Microsimulation of backward stochastic differential equations. Int. Stat. Rev., 72(1), 107–121.
Abstract: A mathematical statistical model is needed to obtain an option prime and create a hedging strategy. With formulas derived from stochastic differential equations, the primes for US Dollar/Chilean Pesos currency options using a prime calculator are obtained. Furthermore, a backward simulation of the option prime trajectory is used with a numerical method created for backward stochastic differential equations. The use of statistics in finance is highly important in order to develop complex products.
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